Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? Whats the process behind drug discovery? How do our bodies interact with those chemicals? An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding.The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E. From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success.
Drugs and Drug Targets; Protein Structure and Function; Enzymes: Structure and Function; Receptors: Structure and Function; Receptors and Signal Transduction; Nucleic Acids: Structure and Function; Enzymes as Drug Targets; Receptors as Drug Targets; Nucleic Acids as Drug Targets; Miscellaneous Drug Targets; Pharmacokinetics and Related Topics; Statins; Drug Discovery: Finding a Lead; Drug Design: Optimizing Target Interactions; Drug Design: Optimizing Access to the Target; Getting the Drug to Market; The Design of ACE Inhibitors; Artemisinin and Related Antimalarial Drugs; The Design of Oxamni; Fosfidomycin as an Antimalarial Agent; Combinatorial and Parallel Synthesis; In Silico Drug Design; Quantitative Structure-Activity Relationships; De Novo Design of a Thymidylate Synthase Inhibitor; Antibacterial Agents; Antiviral Agents; Anticancer Agents; Protein Kinase Inhibitors as Anticancer Agents; Antibodies and Other Biologics; Cholinergics, Anticholinergics, and Anticholinestarases; Drugs Acting on the Adrenergic Nervous System; The Opioid Analgesics; Anti-Ulcer Agents; Cardiovascular Drugs; Steroidal Anti-Inflammatory Agents; Design of a Novel Antidepressant; The Design and Development Of Aliskiren; Factor Xa Inhibitors; Reversible Inhibitors of HCV NS-34A Protease;
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