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Metchnikoff and the Origins of Immunology

From Metaphor to Theory

9780195064476
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Description
This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. In this scientific biography, Tauber and Chernyak explore Metchnikoffs development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwins theory of evolution on his progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural andphilosophic sources.
Product Details
OUP USA
83841
9780195064476
9780195064476

Data sheet

Publication date
1991
Issue number
1
Cover
hard cover
Pages count
266
Dimensions (mm)
160 x 242
Weight (g)
674
  • Foreword; Preface; Introduction; Metchnikoffs early embryology; Metchnikoffs embryological studies after 1872; The problem of evolution in Metchnikoffs works; Metchnikoffs emerging concept of inflammation; The phagocytosis theory and its reception; The phagocyte eclipsed; Epilogue:: From metaphor to theory; Notes and references; Appendix A:: Morphologists vs. Darwinians, the modern debate; Appendix B:: Current views of phagocyte function.
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