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Landmark Papers in Pain

Landmark Papers in Pain

Seminal Papers in Pain with Expert Commentaries

9780198834359
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Description
Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice. Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into themodern speciality of pain medicine. Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential readingfor all medical practitioners with an interest in pain medicine.
Product Details
OUP Oxford
83670
9780198834359
9780198834359

Data sheet

Publication date
2018
Issue number
1
Cover
paperback
Pages count
334
Dimensions (mm)
171 x 246
Weight (g)
606
  • Section 1: Historical; Local anaesthetic substitutes for cocaine; Innovative concepts in pain management; Explaining reflex sympathetic dystrophy; The rediscovery of paracetamol; The pharmacology of placebos; Understanding the responsiveness of c-fibres; A new theory of pain; Three determinants of pain; Purinergic nerves: a new type of nerve; Genetic differences in opiate receptors; Endogenous opioids in placebo-induced analgesia; Ethical pain experimentation in conscious animals; Local anaesthetic creams; The backpain revolution; The mechanism of aspirin; Mechanisms of visceral pain in IBS; The effects of morphine on the central nervous system; Opiods in palliative care; Endogenous opioids in the central nervous system; Spinal opioid analgesia in the rat; Section 2: Firsts; The key role of NGF in inflammatory pain processing; Mapping of neurotrophin receptors on adult sensory neurons; Plasticity in somatic receptive fields after nerve injury; Peripheral neural mechanisms of cutaneous hyperalgesia and heat pain; The Cloning and Characterization of CB1; Deorphanisation of ORL-1/LC132 by reverse pharmacology in two landmark studies; The capsaicin receptor; Vanilloid receptor 1 in inflammatory thermal hyperalgesia; A signature of pain in the brain; Cytokines as central to peripheral sensitisation and hyperalgesia; Endogenous opioids mediate stress-induced analgesia; The first crystal structure of an iGluR ligand-binding core; Control of pain initiation by endogenous cannabinoids; Peripheral Analgesia involves Cannabinoid Receptors; Glia: a new pain target; The challenges of animal models of pain; Mechanisms of bone cancer pain; Molecular Structure of the Mu-Opioid Receptor; Milestone Effect of DNIC in our Understanding of Pain; Original description of central sensitisation; Molecular basis for Placebo effect; Section 3: Science; Early discussions on a mechanistic approach to pain; Plasticity: a key concept in pain; The importance of descending modulatory pain systems; Nocebo and its importance in clinical practice; Mechanisms of Action of Acetaminophen for Pain Treatment; Making the link from central sensitization to clinical pain; Section 4: Clinical; Proof of concept: epidural morphine; The Definition of Fibromyalgia; The advent of PCA for post operative analgesia; Undertreatment of pain with metastatic cancer; Faces scales in paediatric pain assessment; Epidural block and phantom limb pain; Clarifying the concept of Breakthrough pain; Section 5: Mechanisms; Paediatric pain epidemiology; Recognising the importance of HIV disease and pain; Fast acting fentanyl for breakthrough pain; The additive analgesia of adrenaline in epidural blockade; What is the clinical relevance of the Likert scale for pain; Post operative pain: assessing the standards; Opioid induced hyperalgesia; CRPS epidemiology; Seminal paper on epidemiology of cancer pain; Endoscopic ultrasound guided coeliac plexus block; Section 6: Neuropathic; Autotomy: an early neuropathic pain model; Risk factors for post amputation pain; Chronic constriction injury (CCI) model of neuropathic pain; Antineuropathic medication combination therapy; RCT evidence for gabapentin in post herpetic neuralgia; Identification of the target of gabapentinoid action in neuropathic pain; Recognition of the importance of Neuropathic pain epidemiology; Botox analgesia for neuropathic pain; DNIC and prediction of chronic post surgical pain; Pregabalin in the reduction of chronic post knee surgery chronic pain; Multidisciplinary Cognitive Behavioural Treatment for Chronic Pain; Disability in Chronic Low Back Pain; Section 7: Psychosocial; The Understanding of Social Effects in Pain; Section 8: Genetics; Congenital insensitivity to pain; Polymorphic CYP2D6 as the Responsible Enzyme of Activation; COMT genotypes in pain responses; The link between NaV1.7 mutation and erythromelalgia; COMT and morphine use in cancer pain; Pioneering use of gene therapy for pain;
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