This centennial history tells the story of how ACP evolved from a small cluster of New York physicians to a global professional organization. Chapter topics include:: First 75 Years:: 1915-1990, Leadership, Annals of Internal Medicine, 1927-2015, MKSAP:: Medical Knowledge Self Assessment Program, Ethics and Professionalism, The Quest for Diversity, Public Policy, Improving Health Care Delivery, The American College of Physicians as an International Organization, The Future of the American College of Physicians and Internal Medicine.