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Principles of Pharmacology
Principles of Pharmacology

Principles of Pharmacology

The Pathophysiologic Basis of Drug Therapy

9780781746786
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Description

Unlike other pharmacology texts organized by drug class, Principles of Pharmacology integrates relevant knowledge from the basic biomedical sciences - physiology, pathophysiology, cell and molecular biology, biochemistry, anatomy, neurobiology, microbiology and immunology - to build an integrated, conceptual understanding of drug therapy. By discussing the therapeutic and adverse actions of drugs in the framework of the drugs mechanism of action, the book enables students to achieve a level of mastery in pharmacology that far surpasses that achieved by rote memorization. The result is a primary pharmacology textbook that is ideal for a systems-based or discipline-based course in pharmacology.

Product Details
Lippincott Williams & Wilkins
42140
9780781746786
9780781746786

Data sheet

Publication date
2004
Issue number
1
Cover
paperback
Pages count
880
Dimensions (mm)
216 x 279
Weight (g)
1878

  • SECTION I FUNDAMENTAL PRINCIPLES OF PHARMACOLOGY. . . 1

  • Drug-Receptor Interactions 3
  • Pharmacodynamics 17
  • Pharmacokinetics 27
  • Drug Metabolism 45

    SECTION II PRINCIPLES OF NEUROPHARMACOLOGY. . . 55
    Section IIA Fundamental Principles of Neuropharmacology, 57

  • Principles of Cellular Excitability and Electrochemical Transmission 59
  • Principles of Nervous System Physiology and Pharmacology 71
    Section IIB Principles of Autonomic and Peripheral Nervous System
    Pharmacology, 87
  • Cholinergic Pharmacology 89
  • Adrenergic Pharmacology 107
  • Local Anesthetic Pharmacology 121
    Section IIC Principles of Central Nervous System Pharmacology, 137
  • Pharmacology of Excitatory and Inhibitory Neurotransmission 139
  • Pharmacology of Dopaminergic Neurotransmission 161
  • Pharmacology of Affective Disorders 179
  • Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System 193
  • General Anesthetic Pharmacology 205
  • Pharmacology of Analgesia 229
  • Pharmacology of Chemical Dependence and Addiction 247

    SECTION III PRINCIPLES OF CARDIOVASCULAR PHARMACOLOGY. . . 265

  • Pharmacology of Cardiac Rhythm 267
  • Pharmacology of Cardiac Contractility 285
  • Pharmacology of Volume Regulation 299
  • Pharmacology of Vascular Tone 317
  • Pharmacology of Hemostasis and Thrombosis 335
  • Pharmacology of Cholesterol and Lipoprotein Metabolism 357
  • Integrative Cardiovascular Pharmacology:: Hypertension, Ischemic Heart Disease, and Congestive Heart Failure 375

    SECTION IV PRINCIPLES OF ENDOCRINE PHARMACOLOGY. . . 401

  • Pharmacology of the Hypothalamus and Pituitary Gland 403
  • Pharmacology of the Thyroid Gland 415
  • Pharmacology of the Adrenal Cortex 425
  • Pharmacology of Reproduction 441
  • Pharmacology of the Endocrine Pancreas 457
  • Pharmacology of Bone Mineral Homeostasis 473

    SECTION V PRINCIPLES OF CHEMOTHERAPY. . . 491

  • Principles of Antimicrobial and Antineoplastic Pharmacology 493
  • Pharmacology of Nucleotide Synthesis 505
  • Pharmacology of DNA Replication and Mitosis 519
  • Pharmacology of Transcription and Translation 535
  • Pharmacology of Viral Replication 545
  • Pharmacology of the Bacterial Cell Wall 565
  • Pharmacology of Fungal Infections 579
  • Pharmacology of Parasitic Infections 587
  • Principles of Combination Chemotherapy 603

    SECTION VI PRINCIPLES OF INFLAMMATION AND IMMUNE PHARMACOLOGY. . . 615

  • Principles of Inflammation and the Immune System 617
  • Pharmacology of Eicosanoids 627
  • Histamine Pharmacology 647
  • Pharmacology of Hematopoietic and Immune Cell Stimulation 655
  • Pharmacology of Immunosuppression 667
  • Integrative Inflammation Pharmacology:: Peptic Ulcer Disease 683
  • Integrative Inflammation Pharmacology:: Asthma 695
  • Integrative Inflammation Pharmacology:: Gout 709

    SECTION VII PRINCIPLES OF TOXICOLOGY. . . 717

  • Principles of Toxicology 719

    SECTION VIII CONTEMPORARY APPROACHES TO DRUG DISCOVERY, DEVELOPMENT AND DELIVERY. . . 745

  • Drug Discovery and Development 747
  • Protein-Based and Gene Therapies 757
  • Drug Delivery Mechanisms 781

See next edition:

Principles of Pharmacology
Principles of Pharmacology
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