In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Quality, Value, and Patient Safety in Orthopedic Surgery. These topics are critical components of contemporary healthcare and are essential for advancing the field, improving patient experiences, and ensuring the sustainability of healthcare systems worldwide. This issue addresses a wide variety of relevant topics, including digital health tools and data analytics that enhance personalized treatment plans and improving overall patient outcomes.