In this issue of Clinics in Perinatology, guest editors Drs. G. Ganesh Konduri and Satyan Lakshminrusimha bring their considerable expertise to the topic of Advances in Respiratory Care of the Newborn. Top experts provide valuable insights into reducing the burden of respiratory morbidity and mortality in neonates, ultimately improving survival and quality of life for the most vulnerable patients. This issue covers cutting-edge advances, management of complex conditions, and today’s innovative therapies.