In this issue of Otolaryngologic Clinics, guest editors Drs. Inna A. Husain and Nikki Johnston bring their considerable expertise to the topic of Laryngopharyngeal Reflux. Although it is suggested that laryngopharyngeal reflux disease (LPRD) accounts for up to 30% of outpatient otolaryngology visits, lack of formal diagnostic criteria, ease of testing, and varied treatment practices can lead to delay in care and high social/economic burden. In this edition, top experts review up-to-date information on pathophysiology of LPRD, including typical and atypical manifestations, role of diagnostic testing, updated treatment guidelines, and future directions of LPRD management.