The fourth edition of this leading text reflects the new direction and growth of the field of haematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of haematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in haematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing haematologist.
Part I. Molecular and Cellular Basis of Hematology
Chapter 1 Anatomy and Physiology of the Gene Chapter 2 Genomic Approaches to the Study of Hematologic Science NEW Chapter 3 Protein Synthesis, Processing, and Degradation REORGANIZED Chapter 4 Protein Architecture: Relationship of Form and Function Chapter 5 Regulation of Cellular Response NEW Chapter 6 Cell Adhesion Chapter 7 Control of Cell Division Chapter 8 Cell Death NEW Chapter 9 Consequences of Genetic Diversity to Hematologic Disease and Treatment NEW
Part II. Immunologic Basis of Hematology
Chapter 10 B-Cell Development Chapter 11 T-Cell and NK-Cell Immunity REORGANIZED Chapter 12 Dendritic Cell Biology NEW Chapter 13 Regulation of Lymphocyte Activation Chapter 14 Lymphocyte Trafficking NEW Chapter 15 Tolerance and Autoimmunity
Part III. Biology of Stem Cells and Disorders of Hematopoiesis
Chapter 16 Stem Cell Model of Hematopoiesis Chapter 17 Anatomy and Physiology of Hematopoiesis Chapter 18 Humeral Regulation of Hematopoiesis NEW Chapter 19 Biology of Erythroppoiesis, Erythroid Differentiation, and Maturation Chapter 20 Granulopoiesis and Monocytopoiesis Chapter 21 Thrombocytopoiesis Chapter 22 Defects in Platelet Production NEW Chapter 23 Inherited Forms of Bone Marrow Failure Chapter 24 Aplastic Anemia Chapter 25 Paroxysmal Nocturnal Hemoglobinuria Chapter 26 Pure Red Cell Aplasia
Part IV. Red Blood Cells
Chapter 27 Pathobiology of the Human Erythrocyte and Its Hemoglobins Chapter 28 Approach to the Adult and Child with Anemia Chapter 29 Anemia of Chronic Diseases Chapter 30 Disorders of Iron Metabolism: Iron Deficiency and Overload Chapter 31 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias Chapter 32 Megablastic Anemias Chapter 33 Thalassemia Syndromes Chapter 34 Pathology of Sickle Cell Disease Chapter 35 Clinical Manifestations and Treatment of Sickle Cell Disease NEW Chapter 36 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias Chapter 37 Red Cell Enzymopathies Chapter 38 Red Cell Membrane Disorders Chapter 39 Autoimmune Hemolytic Anemias Chapter 40 Extrinsic Nonimmune Hemolytic Anemias
Part V. Host Defense and Its Disorders
Chapter 41 Immunoglobulins and Complement Biology REORGANIZED Chapter 42 Normal Phagocyte Structure and Function Chapter 43 Eosinophilia, Eosinophil-Associated Diseases, and the Hypereosinophilic Syndrome Chapter 44 Disorders of Phagocyte Function and Number Chapter 45 Disorders of Lymphocyte Function Chapter 46 Histiocytic Disorders Chapter 47 Lysosomal Storage Diseases: Perspective and Principles Chapter 48 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases Chapter 49 The Spleen and Its Disorders Chapter 50 Basophils, Mast Cells, and Systemic Mastocytosis
Part VI. Hematologic Malignancies
Chapter 51 Cytogenetics and Neoplasia Chapter 52 The Molecular Basis of Neoplasia Chapter 53 Pharmacology and Molecular Mechanism of Action or Resistance of Antineoplastic Agents: Current Status and Future Potential Chapter 54 Principles of Radiation Oncology for Hematologic Malignancies NEW Chapter 55 Clinical Application of Cytokines Chapter 56 Biologic Response Modifiers NEW Chapter 57 Pathobiology of Acute Myeloid Leukemia Chapter 58 Clinical Manifestations of Acute Myeloid Leukemia Chapter 59 Therapy for Acute Myeloid Leukemia Chapter 60 Acute Myeloid Leukemia in Children Chapter 61 Pathobiology of Acute Lymphoblastic Leukemia Chapter 62 Clinical Manifestations of Acute Lymphoblastic Leukemia Chapter 63 Treatment of Childhood Acute Lymphoblastic Leukemia Chapter 64 Acute Lymphoblastic Leukemia in Adults Chapter 65 Myelodysplastic Syndrome Chapter 66 Polycthemia Vera Chapter 67 Chronic Myelogenous Leukemia Chapter 68 Agnogenic Myeloid Metaplasia Chapter 69 Primary Thrombocythemia Chapter 70 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children Chapter 71 Pathobiology of Non-Hodgkin Lymphomas Chapter 72 Pathology and Histogenesis of Hodgkin Disease Chapter 73 Hodgkin Disease: Clinical Manifestations, Staging, and Therapy Chapter 74 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas Chapter 75 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma Chapter 76 Malignant Lymphomas in Childhood Chapter 77 Chronic Lymphocytic Leukemia Chapter 78 Hairy Cell Leukemia Chapter 79 Cutaneous T-Cell Lymphomas Chapter 80 AIDS-Related Lymphomas Chapter 81 Multiple Myeloma and Other Plasma Cell Disorders Chapter 82 Amyloidosis Chapter 83 Atypical Immune Lymphoproliferations Chapter 84 Clinical Approaches to Infections in the Compromised Host Chapter 85 Nutritional Support of Patients with Hematologic Malignancies Chapter 86 Psychosocial Aspects of Hematologic Disorders Chapter 87 Pain Management and Antiemetic Therapy in Hematologic Disorders Chapter 88 Palliative Care NEW Chapter 89 Indwelling Access Devices Chapter 90 Late Complications of Hematologic Disease and Their Therapies NEW
Part VII. Transplantation
Chapter 91 Transplant for Bone Marrow Failure and Autoimmune Disorders NEW Chapter 92 Hematopoietic Stem Cell Transplantation for Genetic Diseases and Immune Deficiencies NEW Chapter 93 Results of Allogeneic Stem Cell Transplantation for Malignant Disorders Chapter 94 Results of Autologous Stem Cell Transplantation for Malignancies Chapter 95 Unrelated Donor Stem Cell Transplantation Therapy Chapter 96 Placental and Umbilical Cord Blood Transplantation Chapter 97 Preparative Regimens for Stem Cell Transplantation Chapter 98 Graft-versus-Host Disease and Graft-versus- Leukemia Effect Chapter 99 Achievement of Tolerance NEW Chapter 100 Graft Engineering to Enhance Engraftment, Reduce Graft-versus- Host Disease, and Provide a Graft-versus-Tumor Effect Chapter 101 Gene Therapy for Hematologic Disorders Chapter 102 Experimental Cell Therapy (include NK-, T-, and dendric cells) Chapter 103 Complications After Stem Cell Transplantation
Part VIII. Hemostasis and Thrombosis
Chapter 104 Megakaryocyte and Platelet Structure Chapter 105 The Molecular Basis for Platelet Function Chapter 106 The Molecular Basis for Platelet Activation Chapter 107 The Blood Vessel Wall Chapter 108 Molecular Basis of Blood Coagulation Chapter 109 Molecular and Cellular Basis of Fibrinolysis Chapter 110 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants Chapter 111 Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History and Differential Diagnosis of Pupura Chapter 112 Laboratory Evaluation of Hemostatic Disorders REORGANIZED Chapter 113 Structure, Biology, and Genetics of Factor VIII Chapter 114 Biochemistry of Factor IX and Molecular Biology of Hemophilia B Chapter 115 Clinical Aspects and Therapy of Hemophilia Chapter 116 Inhibitors in Hemophilia Chapter 117 Other Clotting Factor Deficiencies Chapter 118 Quantitative and Qualitative Disorders of Fibrinogen Chapter 119 Structure, Biology, and Genetics of von Willebrand Factor Chapter 120 Clinical Aspects of and Therapy for von Willebrand Disease Chapter 121 Vitamin K: Metabolism and Disorders Chapter 122 Inhibitors of Blood Coagulation Chapter 123 Disseminated Intrvascular Coagulation Chapter 124 Hemostatic Defects Associated with Dysproteinemias Chapter 125 Disorders of Coagulation and Platelets in the Neonate Chapter 126 Hypercoagulable States Chapter 127 Venous Thromboembolism Chapter 128 Arterial Thromboembolism Chapter 129 Anticoagulation and Thrombolytic Therapy REORGANIZED Chapter 130 Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura Chapter 131 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Chapter 132 Thrombocytopenia Due to Platelet Destruction and Hypersplenism Chapter 133 Hereditary Disorders of Platelet Function Chapter 134 Acquired Disorders of Platelet Function
Part IX. Transfusion Medicine
Chapter 135 Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants Chapter 136 Human Platelet Antigens Chapter 137 HLA and Neutrophil Antigen and Antibody Systems Chapter 138 Principles of Red Blood Cell Transfusion Chapter 139 Principles of Platelet Transfusion Therapy Chapter 140 Principles of Neutrophil (Granulocyte) Transfusions Chapter 141 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins Chapter 142 Intravenous Immunoglobulin NEW Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins Chapter 144 Transfusion Principles for Congenital Coagulation Disorders Chapter 145 Hemapheresis and Cellular Therapy NEW Chapter 146 Practical Aspects of Stem Cell Collection Chapter 147 Transfusion Reactions Chapter 148 Transfusion-Transmitted Diseases Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation
Part X. Consultative Hematology
Chapter 150 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease REORGANIZED Chapter 151 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer Chapter 152 Hematologic Manifestations of Systemic Disease: HIV Infection Chapter 153 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis Chapter 154 Hematologic Aspects of Pregnancy Chapter 155 Hematologic Manifestations of Childhood Illness
Part XI. Special Tests and Procedures
Chapter 156 Bone Marrow Aspiration and Morphology Chapter 157 Automated Analysis of Blood Cells Chapter 158 Laboratory Detection of Hemoglobinopathies and Thalassemias Chapter 159 Antenatal Diagnosis of Hematologic Disorders Chapter 160 Use of Molecular Techniques in the Analysis of Hematologic Diseases Chapter 161 Special Imaging Applications in Hematology NEW Chapter 162 Coagulation Studies and Their Interpretation NEW
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