Hematology

• 1. Anatomy and Physiology of the Gene

• Epigenetics and Epigenomics

Genomic Approaches to Hematology

Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism

Protein Synthesis, Processing, and Trafficking

Protein Architecture: Relationship of Form and Function

Signaling Transduction and Metabolomics

Pharmacogenomics and Hematologic Diseases

Hematopoietic Stem Cell Biology

Stem Cell Model of Hematologic Malignancies

Hematopoietic Microenvironment

Cell Adhesion

Hematopoietic Cell Trafficking and Chemokines

Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

Vascular Growth in Health and Disease

Cytokine/Receptor families and signal transduction

Control of Cell Division

Cell Death

Overview and Compartmentalization of the Immune System

B-Cell Development

T-Cell Immunity

Natural Killer Cell Immunity

Dendritic Cell Biology

Complement and Immunoglobulin biology leading to clinical translation

Tolerance and Autoimmunity

Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

Granulocytopiesis and Monocytopoiesis

Thrombocytopoiesis

Inherited Forms of Bone Marrow Failure

Aplastic Anemia

Paroxysmal Nocturnal Hemoglobinuria

Acquired Disorders of Unilineage Blood Cell Production

Pathobiology of the Human Erythrocyte and Its Hemoglobins

Approach to Anemia in the Adult and Child

Pathophysiology of Iron Homeostasis

Disorders of Iron Metabolism: Iron Deficiency and Overload

Anemia of Chronic Diseases

Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias

Megaloblastic Anemias

Thalassemia Syndromes

Pathobiology of Sickle Cell Disease

Sickle Cell Disease: Clinical Features and Management

Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias

Red Blood Cell Enzymopathies

Red Blood Cell Membrane Disorders

Autoimmune Hemolytic Anemia

Extrinsic Nonimmune Hemolytic Anemias

Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia

Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia

Disorders of Phagocyte Function

Congenital Disorders of Lymphocyte Function

Histiocytic Disorders

Lysosomal Storage Diseases: Perspectives and Principles

Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases

Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications

The CytoGenomic Basis of Hematological Malignancies

Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies

Pathobiology of Acute Myeloid Leukemia

Clinical Manifestations and Treatment of Acute Myeloid Leukemia

Myelodysplastic Syndromes: Biology and Treatment

Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults

Acute Myeloid Leukemia in Children

Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children

Pathobiology of Acute Lymphoblastic Leukemia

Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia

Acute Lymphocytic Leukemia in Adults

Chronic Myeloid Leukemia

The Polycythemias

Essential Thrombocythemia

Primary Myelofibrosis

Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes

Mast Cells and Systemic Mastocytosis

The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas

Origins of Hodgkin Disease

Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy

Origins of Non-Hodgkin Lymphomas

Chronic Lymphocytic Leukemia

Hairy Cell Leukemia

Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)

Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma

Mantle Cell Lymphoma

Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)

Viral-Related Lymphomas

Malignant Lymphomas in Childhood

T-Cell Lymphomas

Multiple Myeloma

Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma

Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)

Clinical Approach to Infections in the Compromised Host

Psychosocial Aspects of Hematologic Disorders

Pain Management and Antiemetic Therapy in Hematologic Disorders

Palliative Care

Late Complications of Hematologic Diseases and Their Therapies

Overview and Historical Perspective of Current Cell-Based Therapies

Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization

IND Enabling Processes for Cell-Based Therapies

Graft Engineering and Cell Processing

Principles of Cell-Based Genetic Therapies

Mesenchymal Stromal Cells

T Cell Therapy of Hematological Diseases

NK Cell-Based Therapies

Immune Checkpoint Blockade in Hematologic Malignancies

Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation

Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults

Unrelated Donor Hematopoietic Cell Transplantation

Haploidentical Hematopoietic Cell Transplantation

Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies

Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy

Complications after Hematopoietic Cell Transplantation

Human Blood Group Antigens and Antibodies

Principles of Red Blood Cell Transfusion

Clinical Considerations in Platelet Transfusion Therapy

Human Leukocyte Antigen and Human Neutrophil Antigen Systems

Principles of Neutrophil (Granulocyte) Transfusions

Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins

Preparation of Plasma-Derived and Recombinant Human Plasma Proteins

Transfusion Therapy for Coagulation Factor Deficiencies

Hemapheresis

Transfusion Reactions to Blood and Cell Therapy Products

Transfusion-Transmitted Diseases

Pediatric Transfusion Medicine

Overview of Hemostasis and Thrombosis

The Blood Vessel Wall

Megakaryocyte and Platelet Structure

Molecular Basis of Platelet Function

Molecular Basis of Blood Coagulation

Regulatory Mechanisms in Hemostasis

Clinical Approach to the Patient with Bleeding or Bruising

Laboratory Evaluation of Hemostatic and Thrombotic Disorders

Acquired Disorders of Platelet Function

Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura

Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution

Heparin-Induced Thrombocytopenia

Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes

Hemophilia A and B

Inhibitors in Hemophilia A and B

Rare Coagulation Factor Deficiencies

Structure, Biology, and Genetics of Von Willebrand Factor

Disseminated Intravascular Coagulation

Hypercoagulable States

The Antiphospholipid Syndrome

Venous Thromboembolism

Mechanical Interventions in Arterial and Venous Thrombosis

Atherothrombosis

Stroke

Acute Coronary Syndromes

Atrial Fibrillation

Peripheral Artery Disease

Antithrombotic Drugs

Disorders of Coagulation in the Neonate

Hematologic Changes of Pregnancy

Hematologic Manifestations of Childhood Illness

Hematologic Manifestations of Systemic Disease: Liver Disease

Hematologic Manifestations of Systemic Disease: Renal Disease

Hematologic Manifestations of Cancer

Integrated Therapies in Patients with Hematologic Diseases

Hematologic Manifestations of AIDS

Hematologic Manifestations of Parasitic Diseases

Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis

The Spleen and Its Disorders

Hematology in Aging

APPENDIX:

Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations