In this issue of Veterinary Clinics:: Small Animal Practice, guest editor Dr. Casey Cazer brings her considerable expertise to the topic of Artificial Intelligence in Small Animal Veterinary Medicine. Top experts provide an introduction to different types of AI tools that are currently or soon-to-be available for veterinary medicine tasks, helping readers learn to evaluate the ethics, regulations, and accuracy of AI tools and how to responsibly implement them into clinical workflows. As the field of AI evolves, veterinarians can continue to follow the principles outlined in this issue to assess new models and clinical tools powered by AI and machine learning.