In this issue of Sleep Medicine Clinics, guest editors Drs. Ray Chaudhury, Karolina Poplowska-Domaszewics, and Naomi Limbachiya bring their considerable expertise to the topic of Synucleinopathies and Sleep. Patients with synucleinopathies often experience disrupted sleep patterns, such as insomnia, excessive daytime sleepiness, REM sleep behavior disorder, and sleep fragmentation. These sleep disturbances can have a significant impact on overall quality of life, and understanding and managing them are crucial aspects of appropriate and effective care and treatment plans.