As functional imaging becomes increasingly important in radiology, practitioners in a wide range of disciplines need to understand more about the quantitive aspects of physiology and pathophysiology. In straightforward language, this book integrates the principles and mathematics of measurements with physiological systems to which the quantitive problems are applied. Although there is an emphasis on clinical management with radionuclides and quantitive procedures in nuclearmedicine, this book has been written with all practitioners in mind and also therefore embraces techniques based on non-radioactive indicators, including contrast agents used in CT, MRI, and ultrasound. Starting from basic mathematics, the book describes the measurement of fundamental physiologicalvariables, like transit time, clearance, and blood flow, and goes on to cover the perpheral circulation and microvascular solute transfer, the pharmacokinetics of agents routinely used in nuclear medicine, as well as scintillation detectors, data processing, and quantification. In separate chapters, measurements in the heart, lung, gastrointestinal tract, liver, blood, genitourinary tract, brain, and skeleton are discussed, and the book finishes with a chapter on questions and workedanswers.
Basic mathematics; Transit time, clearance, distribution volume, and extraction fraction; Measurement of blood flow; Pharmacokinetics of agenda routinely used in nuclear medicine; Scintillation detectors, data processing and quantification; The peripheral circulation and microvascular solute transfer; The heart; The lung; The gastro-intestinal tract and liver; Haematology and the spleen; The genitourinary; The brain; Body fluids, electrolytes and bone; Exercises;
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