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Ocular angiogenesis, or the abnormal growth of blood vessels in the eye, is the cause of major neovascular eye diseases. In addition, retinal and choroidal neovascularization are the major causes of vision loss in this country. With the new era of anti-angiogenic therapies already in practice, ophthalmologists have started treating many ocular diseases including macular degeneration, diabetic retinopathy, and retinal vascular occlusion using anti-angiogenic drugs.
Therapy for Ocular Angiogenesis:: Principles and Practice covers the basic pathophysiology of ocular angiogenesis and strategies for inhibition. The authors discuss the Principles of anti-angiogenic therapy, pre-clinical studies, future drugs on the horizon, drug delivery, and the Practice of the therapy in many ocular diseases. Vision researchers in both academia and industry, as well as clinician scientists, have contributed chapters on different aspects of the angiogenic process, and clinical strategies to fight it. The book also includes chapters that deal with diabetic macular edema, and various therapeutic options for this condition.
A companion website includes the fully searchable text and an image bank.
Opis
I:: PRINCIPLES
1:: Tumor Angiogenesis:: Concept
Judah Folkman (Reproduction of the Hellen Keller Foundation Lecture 2006)
2:: Retinal Neovascularization:: Pathophysiology
Robert Frank
3:: Choroidal Neovascularization:: Pathophysiology
J. Ambati
4:: VEGF the Major Player
Patricia DAmore
5:: IFG-1 in Angiogenesis
Lois Smith
6:: Is It All the VEGF? Other Factors
John Penn
7:: Proteinases and Integrins
Alexander Ljubimov and Arup Das
8:: Endogenous Inhibitors
David Hinton
9:: Macular Edema:: Molecular Mechanisms
Arup Das
II:: PRACTICE
1:: Anti-VEGF Therapies in ARMD in Practice
Jeff Heier
2:: Novel Anti-VEGF Drugs in ARMD Currently in Trials
Quan Nguyen
3:: Safety of Anti-VEGF Drugs
David Boyer and Thomas Friberg
4:: Pharmacokinetics of Anti-VEGF Drugs
Karl Casky
5:: Anti-VEGF Therapies of Retinal Neovascularization
Allen Ho
6:: Anti-VEGF Therapies in Diabetic Macular Edema
Lloyd Aiello
7:: Steroids in ARMD and Macular Edema
Jennifer Lim
8:: Anti-VEGF Therapies in ROP
Antonio Capone
9:: Pharmacotherapy in Retinal Vein Occlusions
Michael Ip
10:: Intravitreal Injection:: Technique and Complications
Elias Reichel
11:: Role of OCT in Management of ARMD and Macular Edema
Srinivas Sadda
12:: Role of Laser in the Era of Pharmacotherapy
Thomas Friberg
13:: PDT:: Is It an Option?
Albert Augustin
14:: Combination Therapy:: Future
Richard Spaide
15:: Gene Therapy in Ocular Angiogenesis
Rajendra Kumar-Singh
16:: Stem Cell Therapy
Maria Grant
17:: Drug Delivery in Posterior Segment:: Challenges
Prithvi Mruthyunjaya and Glenn Jaffe
18:: Corneal Neovascularization
Bala Ambati
19:: Neovascular Glaucoma
James Tsai
20:: Financial Impact of Anti-Angiogenic Therapy
George Williams
21:: Future of Anti-Angiogenic Therapy
Anthony Adamis