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Medical Microbiology
9780723432593
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Opis
The latest edition of this internationally popular textbook has been substantially updated and improved to keep it at the forefront of clinical microbiology. Its systems-based approach emphasizes the microbiology of the agents responsible for the diseases that affect individual areas of the body. Over 250 full-color diagrams clarify complicated concepts-paired with color clinical photographs that demonstrate the clinical relevance of the science.
Szczegóły produktu
47903
9780723432593
9780723432593
Opis
- Rok wydania
- 2003
- Numer wydania
- 3
- Oprawa
- miękka foliowana
- Liczba stron
- 648
- Waga (g)
- 2077
- I. THE ADVERSARIES: PARASITES
1. Microbes as Parasites
The Varieties of Microbes . Living Inside or Outside Cells . Systems of Classification
The Organisms
2. Bacteria
3. Viruses
4. Fungi
5. Protozoa
6. Helminths and Arthropods
7. Prions
8. The Host-Parasite Relationship
The Normal Flora . Symbiotic Association . The Characteristics of Parasitism . The Evolution of Parasitism
II. THE ADVERSARIES: HOST DEFENSES
9. The Innate Defenses of the Body
Defense Against Entry into the Body . Defenses Once the Microorganism Penetrates the Body
10. Adaptive Responses - a Quantum Leap in Effective Defense
The Role of Antibodies . The Role of T Lymphocytes/MHC . Extracellular Attack on Large Infectious Agents . Local Defenses at Mucosal Surfaces
11. The Cellular Basis of Adaptive Immune Responses
B and T Cell Receptors . Selection & Clonal Expansion of Lymphocytes . Role of Memory Cells . T-independent and T-dependent Antigens . Cytokines . Regulatory Mechanisms . Tolerance Mechanisms
III. CONFLICTS
12. Conflicts: Background to Infectious Disease
Host-Parasite Relationships . Causes of Infectious Diseases . The Biologic Response Gradient
13. Entry, Exit and Transmission
Sites of Entry . Exit and Transmission . Types of Transmission . Transmission from Animals
14. Innate Defenses in Action
Complement . C-reactive Protein . Phagocytosis . Cytotoxicity by Lymphocytes and Natural Killer Cells . Cytotoxic Lipids . Cytokines . Fever
15. Spread and Replication
Features of Surface and Systemic Infections . Mechanisms of Spread through the Body . Genetic Determinants of Spread and Replication . Other Factors Affecting Spread and Replication
16. Adaptive Immunity in Action
17. Parasite Survival Strategies and Persistent Infections
Parasite Survival Strategies . Concealment of Antigens . Antigenic Variation . Immunosuppression . Persistent Infections
18. Pathologic Consequences of Infection
Pathology Due to Direct Effects of the Microorganism . Pathologic Activation of Innate Immune Mechanisms . Pathologic Consequences of the Adaptive Immune Response . Skin Rashes . Viruses and Cancer . Microbes & Diseases of obscure origin
IV. CLINICAL MANIFESTATIONS AND DIAGNOSIS OF INFECTIONS BY BODY SYSTEM
19. Upper Respiratory Tract Infections
The Clinical Manifestations of Infection . The Common Cold . Pharyngitis and Tonsillitis . Otitis and Sinusitis . Acute Epiglottitis . Oral Cavity Infections . Laryngitis and Tracheitis . Diphtheria . Summary
20. Lower Respiratory Tract Infections
Acute Infections of the Lower Respiratory Tract . Chronic Infections of the Lower Respiratory Tract . Parasitic Infections of the Lower Respiratory Tract . Summary
21. Urinary Tract Infections
Acquisition and Etiology . Pathogenesis of UTIs . Clinical Features and Complications . Laboratory Diagnosis of UTIs . Treatment of UTIs . Prevention of Urinary Tract Infections . Summary
22. Sexually Transmitted Diseases
STDs and Sexual Behavior . Syphilis . Gonorrhea . Chlamydial Infection . Other Causes of Inguinal Lymphadenopathy . Mycoplasmas and Non-gonococcal Urethritis . Other Causes of Vaginitis and Urethritis . Genital Herpes . Human Papillomavirus Infection . HIV and AIDS . Opportunistic STDs . Arthropod Infestations . Summary
23. Gastrointestinal Tract Infections
Diarrheal Diseases . Helicobacter pylori and Gastric Ulcer Disease . Parasites and the Gastrointestinal Tract . Systemic Infection Initiated in the Gastrointestinal Tract . Hepatitis & other diseases of liver . Summary
24. Obstetric and Perinatal Infections
Infections Occurring in Pregnancy . Congenital Infections . Infections Occurring Around the Time of Birth
25. Central Nervous System Infections
Invasion of the Central Nervous System . The Bodys Response to Invasion . Bacterial Meningitis . Fungal Meningitis . Protozoal Meningitis . Viral Meningitis . Encephalitis . Neurologic Diseases of Possible Viral Etiology . Slow Virus Infection . Brain Absceses . Encephalopathy Due to Scrapie-type Agents . Postvaccinial and Postinfectious Encephalitis . CNS Disease Due to Helminth Parasties . Tetanus and Botulism . Summary
26. Infections of the Eye
Conjunctivitis . Infection of the Deeper Layers of the Eye
27. Infections of Skin
Infections of the Skin . Bacterial Infections of Skin, Soft Tissue and Muscle . Mycobacterial Diseases of the Skin . Fungal Infections of the Skin . Parasitic Infections of the Skin . Mucocutaneous Lesions Caused by Viruses . Other Infectious Causes of Maculopapular Rashes . Summary
28. Infections of Muscle, Joints, Bone and Hemopoietic System
Kawasaki Syndrome . Muscle infections . Joint and Bone Infections . Infections of the Hemopoietic System
29. Worldwide Virus Infections
Measles . Mumps . Rubella . Cytomegalovirus Infection . EBV Infection . Other Human Herpesvirus (HHV) Infections . Smallpox . Summary
30. Vector-borne Infections
Arboviruses and Hemorrhagic Fevers . Rickettsial Infections . Borrelia Infections . Protozoal Infections . Helminth Infections
31. Zoonoses
Arenavirus Infections . Korean Hemorrhagic Fever . Marburg and Ebola Hemorrhagic Fevers . Q Fever . Anthrax . Plague . Yersinia enterocolitica Infection . Tularemia . Pasteurella multocida Infection . Leptospirosis . Rat Bite Fever . Brucellosis . Helminth Infections
32. Fever of Unknown Origin
Definitions of Fever of Unknown Origin . Causes of FUO . Investigation of Classical FUO . Treatment of FUO . FUO in Specific Patient Groups . Infective Endocarditis . Summary
33. Infections in the Compromised Host
The Compromised Host . Deficient Innate Immunity . Deficient Adaptive Immunity . Pathogens that Infect the Compromised Host . Clinical management of compromised host . Summary
V. DIAGNOSIS AND CONTROL
34. Strategies for Control: An Introduction
Epidemiologic considerations . Importance of diagnosis . Chemotherapy Versus Vaccination . Control Versus Eradication
35. Diagnosis of Infection and Assessment of Host Defense Mechanisms
Aims of the Clinical Microbiology Laboratory . Specimen Protocols . Non-cultural Techniques for the Laboratory Diagnosis of Infection . Cultivation (Culture) of Microorganisms . Identification of Microorganisms Grown in Culture . Antibody Detection Methods for the Diagnosis of Infection . Assessment of Host Defense Systems
36. Attacking the Enemy: Antimicrobial Agents and Chemotherapy
Selective Toxicity Discovery and Design of Antimicrobial Agents . Classification of Antibacterial Agents . Inhibitors of Cell Wall Synthesis . Inhibitors of Protein Synthesis . Inhibitors of Nucleic Acid Synthesis . Other Agents That Affect DNA . Inhibitors of Cytoplastic Membrane Function . Antibacterial Agents in Practice . Antiviral Agents . Antifungal and Antiparasitic Agents . Use and Misuse of Antimicrobial Agents . Resistance to Antimicrobials . Summary
37. Boosting Host Defense: Vaccination
The Aims of Vaccination . Requirements of a Good Vaccine . Types of Vaccine . Special Considerations . Current Vaccine Practice . Community-based Control by Vaccination . Factors Influencing the Success of Vaccination
38. Passive and Non-specific Immunotherapy
Passive Immunization with Antibody . Non-specific Cellular Immunostimulation . Correction of Host Immunodeficiency
39. Hospital Infection: Sterilization and Disinfection
Common Hospital-acquired Infections . Important Causes of Hospital Infection . Sources and Routes of Spread of Hospital Infection . Host Factors and Hospital Infection . The Consequences of Hospital Infection . Prevention of Hospital Infection . Investigating Hospital Infection . Sterilization and Disinfection . Deciding Whether Sterilization or Disinfection Should Be Used . Techniques for Sterilization . Controlling Sterilization and Disinfection . Summary
Pathogen Review
Answers
Index
Appendix I: Protocols for Specimen Processing
Protocols for Specimen Processing . Specimen Collection . Transport of Specimens . Specimen Processing
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