Knowledge of cellular and molecular physiology is fundamental to understanding tissue and organ function as well as integrative system physiology. This textbook will help medical and graduate students bridge the gap between basic biochemistry and molecular cell biology. There is a strong emphasis on functional relevance of cellular concepts to systems physiology. The text is illustrated throughout to help the reader understand fundamental concepts of cellular physiology. Learning tools in each chapter are supplemented with an extensive appendix that includes multiple choice questions with answers, a review of mathematical techniques and a summary of basic circuit theory.