In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Seth A. Gross brings his considerable expertise to the topic of Artificial Intelligence in Endoscopy. With its heavy reliance on endoscopic and radiologic imaging, the field of gastroenterology is prime to utilize the many advances in artificial intelligence (AI) over the past two decades. In this issue, top experts discuss the intersection of AI and diagnostic modalities in gastrointestinal endoscopy, providing today’s clinicians with up-to-date information on current and future applications.