Neurobiology of PTSD outlines the basic neural mechanisms that mediate complex responses and adaptations to psychological trauma, describing how these biological processes are impaired in individuals with posttraumatic stress disorder (PTSD). Throughout three comprehensive sections, expert authors present detailed analysis of the neural circuitry of emotion, biological findings in post-traumatic stress disorder, and neuroscience informed treatment and prevention. This bookis a foundational resource for psychiatrists, neuroscientists, psychologists, and allied health professionals.
Contributors; Section 1 Neural Circuitry of Emotion; Introduction to Section 1; Israel Liberzon, Kerry Ressler; 1. Behavioral Neuroscience of Circuits involved in Fear Processing; Elizabeth P. Bauer, Dennis Pare; 2. Cellular Physiology of the Basolateral Complex of the Amygdala and its Modulation by Stress; Brendan OFlaherty, Chia Chun Hsu, Anzar Abbas, D.G. Rainnie; 3. Generalizations of learned fear; Joseph E. Dunsmoor, Rony Paz; 4. Neural circuits for context processing in aversive learning and memory; Stephen Maren; 5. Adult hippocampal neurogenesis, generalization, and PTSD; Kristen C. Klemenhagen, Abby J. Fyer, H. Blair Simpson, Rene Hen; 6. Behavioral Neuroscience of Circuits involved in Arousal Regulation; Arash Javanbakht, Gina R. Poe; 7. Limbic Pathways to Stress Control: Regulation of the HPA Axis; James P. Herman; 8. Prefrontal regulation of emotion; Annmarie MacNamara, K. Luan Phan, PhD; Section 2 Biological Findings in PTSD; Introduction to Section 2; Israel Liberzon, Kerry Ressler; 9. Genetics of PTSD; Jennifer A. Sumner, Angela C. Bustamante, Karestan C. Koenen, Monica Uddin; 10. Neurobiological pathways involved in fear, stress, and PTSD; Christine Heim, Charles B. Nemeroff; 11. Inflammation and immune function in PTSD; Jennifer C. Felger, Ebrahim Haroon, Andrew H. Miller; 12. Secondary messenger systems and other molecular pathways implicated in PTSD; Ulrike Schmidt; 13. Human Psychophysiology and PTSD; Tanja Jovanovic, Seth Davin Norrholm; 14. Human fMRI in PTSD; Marie-France Mari, Mohammed R. Milad; 15. Translational research from animal models to humans; Shigeru Morinobu, Shigeto Yamamoto, Manabu Fuchikami; Section 3 Neuroscience informed Intervention, Treatment, and Prevention; Introduction to Section 3; Israel Liberzon, Kerry Ressler; 16. Mechanisms of action of psychotherapy; Sheila Rauch, Israel Liberzon; 17. Mechanisms of action of medication treatment; Thomas D. Geracioti, Jeffrey R. Strawn, Matthew D. Wortman; 18. Novel prevention, intervention, and treatment approaches; Jonathon R. Howlett, Murray B. Stein;
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