In this issue of Veterinary Clinics of North America:: Equine Practice, guest editor Dr. Britta Leise brings her considerable expertise to the topic of Complications in Equine Practice. Top experts discuss complications from a wide range of conditions, diagnostic and surgical procedures, medical therapies, and disciplines. This issue aims to increase awareness among veterinarians working in equine practice of possible complications and what steps can be taken to prevent and address when they occur.