Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy ofischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growth factors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.
Part I:: Developmental and Normal Biology of the Vasculature; Embryonic Development of the Vascular System; Cellular Mechanisms of Angiogenesis; Heparan Sulfate Proteoglycans; Molecular Mechanisms of the Fibroblast Growth Factor Family; Molecular Mechanisms of the Vascular Endothelial Growth Factor Family; Platelet Derived Growth Factor and other Modulators of Angiogenesis; Part II:: Angiogenesis in the pathophysiology and treatment of ischemic vascular disease; Angiogenesis in Atherosclerosis and Restenosis; Collateral Circulation of the Heart; Angiogenesis in Non-Ischemic Myocardium; Animal Models of Angiogenesis in Cardiovascular Tissues; Growth Factor Delivery Strategies; Coronary Microcirculation and Angiogenesis; Therapeutic Angiogenesis in Myocardial Ischemia; Therapeutic Angiogenesis in peripheral limb ischemia;
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