In this issue of Surgical Clinics, guest editor Dr. Mathew Chung brings his considerable expertise to the topic of Genetics and Screening for the General Surgeon. Genetics and screening have become pivotal in the field of medicine, especially in the early detection and treatment of various cancers. The integration of genetic information into clinical practice allows for more precise risk assessment, personalized treatment plans, and targeted preventive measures. This issue contains two sections of relevance to the general surgeon:: risk reduction possible, and risk reduction not possible.