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Dubois' Lupus Erythematosus and Related Syndromes

Dubois' Lupus Erythematosus and Related Syndromes

9780323932325
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Opis
For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the 10th edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.
Szczegóły produktu
Elsevier
99582
9780323932325
9780323932325

Opis

Rok wydania
2024
Numer wydania
10
Oprawa
miękka foliowana
Liczba stron
816
Waga (g)
2470
  • SECTION 1 What Is Lupus?
    1 History of Lupus
    2 Definition and Classification of Lupus and Lupus-Related Disorders
    3 The Epidemiology of Lupus
    SECTION 2 Pathogenesis
    4 Overview of Lupus Pathogenesis
    5 Genetics of SLE
    6 Single Gene Defects and Autoinflammation: Relation to Lupus
    7 Epigenetics of Lupus
    8 The Role of the Environment and Microbiome in Lupus
    9 The Innate Immune System in SLE
    10 B Cells and Generation of Antibodies
    11 T cells
    12 Immunoregulatory Cells and Networks in Lupus
    13 Cytokines in Lupus
    14 Metabolic Control of Immunopathogenesis in Systemic Lupus Erythematosus
    15 Animal Models of Systemic Lupus Erythematosus (SLE)
    SECTION 3 Mechanisms of Tissue Injury
    16 Abnormalities in Clearance of Immune Complexes and Dying Cells in Lupus
    17 Complement and Systemic Lupus Erythematosus
    18 Apoptosis and Inflammatory Forms of Cell Death
    19 Tissue Damage in Lupus: Free Radicals and Fibrosis
    20 Lupus Nephritis
    21 Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus
    22 Pathogenesis of Cutaneous Lupus
    23 Pathogenesis of Neuropsychiatric Lupus
    24 Pathogenesis of Sjögren Syndrome
    SECTION 4 Autoantibodies
    25 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes
    26 Antibodies Against Extractable Nuclear Antigens(RNP, Sm, SS-A/Ro, and SS-B/La)
    27 Other Autoantibodies: Antibodies to C1q, Lipoprotein, and Endothelial Cells
    28 Pathogenesis of Antiphospholipid Antibody Syndrome
    29 Drug-Induced Lupus
    SECTION 5 Clinical Aspects of Lupus Erythematosus
    30 Overview and Clinical Presentation
    31 Skin Disease in Cutaneous Lupus Erythematosus
    32 The Musculoskeletal System and Bone Metabolism
    33 Lupus and the Cardiovascular System
    34 Pulmonary Manifestations of Systemic Lupus Erythematosus
    35 Lupus and the Nervous System: Clinical Presentation, Diagnosis, and Treatment
    36 Gastrointestinal and Hepatic Manifestations
    37 The Gut Microbiome and Lupus Pathogenesis
    38 Hematologic and Lymphoid Abnormalities in SLE
    39 Neonatal Lupus: Pathogenesis and Clinical Approaches
    40 Pregnancy and Reproductive Health Issues in Systemic Lupus Erythematosus
    41 Systemic Lupus Erythematosus in Childhood and Adolescence
    42 Clinical Aspects of Antiphospholipid Syndrome
    43 Lupus and Infections
    44 Ocular, Aural, and Oral Manifestations of Lupus
    45 Clinical Aspects of Sjögren’s Disease
    46 Clinical Presentations of Lupus in the Kidney and Urogenital System
    47 The Endocrine System and Hormones in Lupus
    SECTION 6 Assessment of Lupus
    48 Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Laboratory Tests in Systemic Lupus Erythematosus
    49 Differential Diagnosis and Disease Associations
    50 Incomplete Lupus, Undifferentiated Connective Tissue Disease, and Mixed Connective Tissue Disease
    51 Clinical Markers, Metrics, Indices, and Clinical Trials
    SECTION 7 Management of Lupus
    52 Principles of Therapy, Local Measures, and NSAIDs
    53 Antimalarial Medications
    54 Systemic Glucocorticoid Therapy for SLE
    55 Immunosuppressive Drug Therapy
    56 Complementary and Integrative Health Approaches
    57 Specialized and Niche Therapies
    58 Adjunctive and Preventive Measures
    59 Management of Cutaneous Lupus Erythematosus
    60 Targeted Therapies in SLE
    61 Management of Lupus Nephritis
    62 Management of Sjögren Disease Syndrome
    SECTION 8 Outcomes
    63 Socioeconomics, Disparities, and Disability
    64 Prognosis and Mortality of Systemic Lupus Erythematosus
    65 Future Directions: Therapeutics
    66 Expanding the Opportunities to Effectively Treat Patients: Clinical Considerations
    Index
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