In this issue of Radiologic Clinics, guest editors Drs. Eliot Siegel, Babak Saboury, Faraz Farhadi, and Munir Ghesani bring their considerable expertise to the topic of Practical Positron Emission Tomography for Radiologists. Top experts discuss topics such as principles of radiopharmaceuticals in PET; key technologies in PET instrumentation; FDG PET/CT in oncology:: detecting metabolic changes for cancer diagnosis and management; somatostatin receptor imaging with DOTATATE PET/CT; and much more.