Volume 1

PART I. PERSPECTIVES

1. Milestones in the History of Pulmonary Medicine, Alfred P. Fishman

PART II. SCIENTIFIC BASIS OF LUNG FUNCTIONIN HEALTH AND DISEASE

Section One. Architecture for Normal Lung Function

2. Functional Design of the Human Lung for Gas Exchange, Matthias Ochs & Ewald R. Weibel

3.The Respiratory Muscles, Marc Decramer

4. The Genetic, Molecular, and Cellular Basis of Lung Development, Stijn DeLanghe, Pierre Del Moral, Denise Tefft, Saverio Bellusci, & David Warburton

5. Development and Growth of the Lung, Johannes C. Schittny & Peter H. Burri

6. Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology, Reynold A. Panettieri, Jr.

7. Pulmonary Surfactant System and Alveolar Homeostasis, Jeffrey A. Whitsett & Ann D. Horowitz

8. Transport Function of Airway Epithelia and Submucosal Glands, Paul B. McCray, Jr. & Michael J. Walsh

Section Two.Physiological Principles of Normal Lung Function

9. Pulmonary Mechanics, Murray D. Altose

10. Control of Ventilation, Neil S. Cherniack

11. Ventilation, Pulmonary Blood Flow, and Ventilation-Perfusion Relationships, Peter D. Wagner

12. Diffusion, Chemical Reactions, and Diffusing Capacity, Robert A. Klocke

13. Blood-Gas Transport, Michael P. Hlastala, Erik R. Swenson, & Robert A. Klocke

14. Acid-Base Balance, Stanley Goldfarb & Kumar Sharma

Section Three. The Lungs in Different Physiological States

15.Exercise, Integration, and Adaptation, Alfred P. Fishman

16. Breathing in Exercise, Brian J. Whipp & Susan A. Ward

17.The Lungs in Pregnancy, Daniel B. Rosenbluth & John Popovish, Jr.

18.Aging of the Respiratory System, Edward J. Campbell

Section Four. Lung Immunology

19.Pulmonary Defense Mechanisms against Infections, Herbert Y. Reynolds and Jack A. Elias

20.Lymphocyte- and Macrophage-Mediated Inflammation in the Lung, Frederic F. Little, Kevin C. Wilson, Jeffrey S. Berman, and David M. Center

21.Mast Cells and Eosinophils, Edward S. Schulman and Peter H.S. Sporn

22.Antibody-Mediated Lung Defenses and Humoral Immunodeficiency, David N. Weissman, Kenneth S. Landreth, and Nevin W. Wilson

Section Five.Lung Injury and Repair

23. Cytokines and Chemokines in Lung Inflammation and Injury, Robert M. Strieter, John A. Belperio, and Michael P. Keane

24.Leukocyte Accumulation in Pulmonary Disease, Nicholas W. Lukas and Peter A. Ward

25. Oxidative and Nitrosative Lung Injury, John D. Lang, Jr., Ian C. Davis, Rakesh P. Patel, and Sadis Matalon

26.The Pathogenesis of Pulmonary Fibrosis, Moises Selman & Annie Pardo

PART III. SYMPTOMS AND SIGNS OF RESPIRATORY DISEASE

Section Six. Clinical Approach to the Patient

27. Approach to the Patient with Respiratory Symptoms, Darren B. Taichman and Alfred P. Fishmana

28. Skin Disease in Patients with Pulmonary Disease, Jeffrey P. Callen

29. Pulmonary-Systemic Interactions, Alfred P. Fishman

Section Seven. Diagnostic Procedures

30. Radiographic Evaluation of the Chest, Wallace T. Miller

31. Pulmonary Cytopathology, Prabodh K. Gupta and Zubair W. Baloch

32. Interventional Radiology in the Thorax: Nonvascular and Vascular Applications, Aalpen A. Patel and Scott O. Trerotola

33. Scintigraphic Evaluation of Pulmonary Disease, Abass Alavi, Daniel F. Worsley, and Ghassan El-Haddad

34.Pulmonary Function Testing, Michael A. Grippi and Gregory Tino

35. Principles and Applications of Cardiopulmonary Exercise Testing, Karl T. Weber and Ahmad Munir

36. Bronchoscopy, Transthoracic Needle Aspiration, and Related Procedures, Anil Vachani, Luis Seijo, Michael Unger, and Daniel Sterman

37. Thoracoscopy, Larry R. Kaiser

38. Perioperative Respiratory Considerations, Horace M. DeLisser and Michael A. Grippi

39. Evaluation of Impairment and Disability Due to Lung Disease, Paul E. Epstein

PART IV. OBSTRUCTIVE LUNG DISEASES

Section Eight. Chronic Obstructive Pulmonary Disease

40. Pathologic Features of Chronic Obstructive Pulmonary Disease: Diagnostic Criteria and Differential Diagnosis, Joanne L. Wright and Andrew Churg

41. Chronic Obstructive Pulmonary Disease: EpidemiologyPathophysiology, and Pathogenesis, Robert M. Senior and Jeffrey J. Atkonson

42.Chronic Obstructive Pulmonary Disease: Clinical Course and Management, Robert A. Wise

43. Cigarette Smoking and Disease, Stephen. I. Rennard, Lisa M. Hepp, and David M. Daughton

44. Rehabilitation in Chronic Obstructive Pulmonary Disease and Other RespiratoryDisorders, Andrew L. Ries

Section Nine: Asthma

45. The Biology of Asthma, Sameer K. Mathur and William W. Busse

46. Asthma: Epidemiology, Andrea J. Apter and Scott T. Weiss

47. Aspirin- and Exercise-Induced Asthma, Gregory P. Geba

48.Asthma: Clinical Presentation and Management, Rodolfo M. Pascual, JeRay J. Johnson, and Stephen P. Peteres

49. Allergic Bronchopulmonary Aspergillosis (Mycosis), Geoffrey Chupp and Carolyn L. Rochester

Section Ten:Other Obstructive Disorders

50. Upper Airway Obstruction in Adults, Sidney S. Braman and Muhanned A. Abu-Hijleh

51. Cystic Fibrosis, Judith Voynow and Thomas F. Scanlin

52. Bronchiolitis, Talmadge E. King, Jr. and Brent W. Kinder

53. Bullous Disease of the Lungs, David M.F. Murphy and Alfred P. Fishman

PART V. OCCUPATIONAL AND ENVIRONMENTAL DISORDERS

Section Eleven: Occupational and Environmental Disorders

54. Occupational Lung Disorders: General Principles and Approaches, Mridu Gulati and Carrie A. Redlich

55. Asbestos-Related Lung Disease, William N. Rom

56. Chronic Beryllium Disease and Hard-Metal Lung Diseases, Mary Elizabeth Kreider and Milton D. Rossman

57. Coal Workers Lung Diseases and Silicosis, Edward L. Petsonk and John E. Parker

58. Occupational Asthma, Byssinosis, and Industrial Bronchitis, J. Allen D. Cooper, Jr.

59.Acute and Chronic Responses to Toxic Inhalations, Robert P. Dickson and David A. Schwartz

Section Twelve. Environmental Disorders

60. Indoor and Outdoor Air Pollution, Jonathan M. Samet and Mark J. Utell

61. High Altitude Physiology and Clinical Disorders, Sukhamay Lahiri, Santhosh M. Baby, and Camillo DiGiulio

62. Diving Injuries and Air Embolism, James A. Clark

63. Thermal Lung Injury and Acute Smoke Inhalation, Daniel L. Traber and Perenlei Enkhbaatar

PART VI: DRUG-INDUCED LUNG DISEASES

64. Pulmonary Toxicity Associated with Chemotherepeutic Agents, Lynn T. Tanoue and John R. McArdle

65. Drug-Induced Lung Disease due to Nonchemotherapeutic Agents, Hilary C. Cain

PART VII: INTERSTITIAL AND INFLAMMATORY LUNG DISEASES

Section Thirteen. Immunologic and Interstitial Diseases

66. Interstitial Lung Disease: A Clinical Overview and General Approach, Michael A. Nead and David G. Morris

67. Systemic Sarcoidosis, David R. Moller

68. Idiopathic Pulmonary Fibrosis, Eric B. Meltzer and Paul W. Noble

69. Hypersensitivity Pneumonitis, Richard I. Enelow

70. Radiation Pneumonitis, Kenneth B. Roberts and Sara Rockwell

71. Pulmonary Manifestations of the Collagen Vascular Diseases, Gregory P. Cosgrove and Marvin I. Schwarz

72. The Eosinophilic Pneumonias, Kristina Crothers and Carolyn L. Rochester

Section Fourteen. Depositional and Infiltrative Disorders

73. Depositional Diseases of the Lungs, Robert J. Homer

74. Pulmonary Langerhans-Cell Histiocytosis, Talmadge E. King, Jr.

75. Pulmonary Lymphangioleiomyomatosis, Talmadge E. King, Jr.

76. The Lungs in Patients with Inborn Errors of Metabolism, Masazuni Adachi and Francis A. Caccavo

PART VIII. ALVEOLAR DISEASES

77. Alveolar Hemorrhage Syndromes, Joseph P. Lynch, III and James W. Leatherman

78. Mechanisms of Aspiration Disorders, Richard D. Zorowitz

79. Pulmonary Alveolar Proteinosis, Bruce C. Trapnell and Jonathan Puchalski

Appendixes

Appendix A: Normal Values: Typical Values for a 20-Year-Old Seated Man

Appendix B: Terms and Symbols in Respiratory Physiology

Index

Chapter 82
The Pulmonary Circulation

Chapter 83
Pulmonary Hypertension and Cor Pulmonale

Chapter 84
Pulmonary Thromboembolic Disease

Chapter 85
Pulmonary Edema

Chapter 86
Pulmonary Vasculitis

Chapter 87
Pulmonary Arteriovenous Malformations
Part Ten
DISORDERS OF THE PLEURAL SPACE

Chapter 88
Pleural Fluid Dynamics and Effusions

Chapter 89
Nonmalignant Pleural Effusions

Chapter 90
Malignant Pleural Effusions

Chapter 91
Pneumothorax

Chapter 92
Malignant Mesothelioma and Other Primary Pleural Tumors
Part Eleven
DISEASES OF THE MEDIASTINUM

Chapter 93
The Mediastinum: Overview, Anatomy, and Diagnostic Approach

Chapter 94
Nonneoplastic Disorders of the Mediastinum

Chapter 95
Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies

Chapter 96
Acquired Lesions of the Mediastinum: Benign and Malignant
Part Twelve
DISORDERS OF THE CHEST WALL, DIAPHRAGM, AND SPINE

Chapter 97
Nonmuscular Diseases of the Chest Wall

Chapter 98
Effects of Neuromuscular Diseases on Ventilation

Chapter 99
Pulmonary Rehabilitation in Neuromuscular Diseases
Part Thirteen
SLEEP AND SLEEP DISORDERS

Chapter 100
The Stages of Sleep

Chapter 101
Changes in the Cardiorespiratory System during Sleep

Chapter 102
Sleep Apnea Syndromes

Chapter 103
Differential Diagnosis and Evaluation of Sleepiness
Part Fourteen
SURGICAL ASPECTS OF PULMONARY MEDICINE

Chapter 104
Perioperative Care of the Patient Undergoing Lung Resection

Chapter 105
Thoracic Trauma

Chapter 106
Lung Transplantation
Part Fifteen
NEOPLASMS OF THE LUNGS
Section 15
Cancer of the Lungs

Chapter 107
Genetic and Molecular Changes of Human Lung Cancer

Chapter 108
Epidemiology of Lung Cancer

Chapter 109
Cigarette Smoking and Health Policy

Chapter 110
The Solitary Pulmonary Nodule: A Systemic Approach

Chapter 111
The Pathology of Non–Small Cell Lung Carcinoma

Chapter 112
Non–Small Cell Lung Cancer—Clinical Aspects, Diagnosis, Staging, andNatural History

Chapter 113
Part I: Treatment of Non–Small Cell Lung Cancer: Surgical
Part II: Treatment of Non–Small Cell Lung Cancer: Chemotherapy
Part III: Treatment of Non–Small Cell Lung Cancer: Radiation Therapy

Chapter 114
Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History

Chapter 115
Primary Lung Tumors Other Than Bronchogenic Carcinoma: Benign and Malignant

Chapter 116
Extrapulmonary Syndromes Associated with Lung Tumors

Chapter 117
Pulmonary Metastases
Section 16
Lymphoproliferative Disorders

Chapter 118
Lymphoproliferative and Hematologic Diseases Involving the Lung
Part Sixteen
INFECTIOUS DISEASES OF THE LUNGS
Section 17
General Issues

Chapter 119
Microbial Flora and Colonization of the Respiratory Tract

Chapter 120
Pulmonary Clearance of Infectious Agents

Chapter 121
Approach to the Patient with Pulmonary Infections

Chapter 122
Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia

Chapter 123
Local Therapy and Pharmacokinetics of Antibiotics in the Lungs

Chapter 124
Vaccination for Pulmonary Infections

Chapter 125
Microbial Virulence Factors in Pulmonary Infections
Section 18
Pulmonary Infectious Syndromes

Chapter 126
Infections of the Upper Respiratory Tract

Chapter 127
Acute Bronchitis and Community-Acquired Pneumonia

Chapter 128
Pneumonia in Childhood

Chapter 129
Aspiration Disease and Anaerobic Infection

Chapter 130
Empyema and Lung Abscess

Chapter 131
Mediastinitis

Chapter 132
Bronchiectasis

Chapter 133
Systemic Infection, the Sepsis Syndrome, and the Lungs
Section 19
Special Hosts and Opportunistic Infections

Chapter 134
Introduction: Pulmonary Infection in Special Hosts

Chapter 135
HIV Infection and Opportunistic Pulmonary Infections in AIDS

Chapter 136
Pulmonary Infections in Neutropenia and Cancer

Chapter 137
Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation

Chapter 138
Pneumonia in the Organ Transplant Patient

Chapter 139
Pulmonary Infections in Patients with Primary Immune Defects

Chapter 140
Postoperative Pneumonia

Chapter 141
Respiratory Infections in the Economically Disadvantaged
Section 20
Specific Microorganisms

Chapter 142
Pneumonias Caused by Gram-Positive Bacteria

Chapter 143
Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia
Chapter 144
Legionellosis

Chapter 145
Mycoplasma, Chlamydia, and “Atypical Pneumonias”

Chapter 146
Actinomycosis and Nocardiosis

Chapter 147
Aspergillus Syndromes, Mucormycosis,and Pulmonary Candidiasis

Chapter 148
Endemic Mycoses of North America: Histoplasmosis, Coccidioidomycosis, andBlastomycosis

Chapter 149
Cryptococcal Infections

Chapter 150
Pneumocystis Carinii

Chapter 151
Viral Infections of the Lung and Respiratory Tract

Chapter 152
The Lung in Human Immunodeficiency Virus Infection

Chapter 153
Emerging Infectious Diseases and Hantavirus Pulmonary Syndromev

Chapter 154
Poliovirus and Other Enterovirus Infections

Chapter 155

Chapter 156

Chapter 157

Chapter 158

Chapter 159

Chapter 160

Chapter 161

Chapter 162

Chapter 163

Chapter 164

Chapter 165

Chapter 166

Chapter 167

Chapter 168

Chapter 169

Chapter 170

Chapter 171

Chapter 172

Chapter 173

Chapter 174

Chapter 175

Chapter 176

Chapter 177

Chapter 178

Chapter 179

Chapter 180

Chapter 181

Chapter 182

APPENDIXES