Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of treatment-resistant mood disordersand reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and interested primary carephysicians.
Treatment-resistant major depressive disorder: Current Definitions, Epidemiology and Assessment; Treatment-resistant bipolar disorder: current definitions, epidemiology and assessment; Determinants of Treatment Resistance: Health Systems and Public Policy Implications; The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders; Predictors of treatment response in major depressive disorder; Predictors of Treatment Response in Bipolar Disorder: Lessons from Longitudinal Studies; Evidence-based Pharmacological Approaches for Treatment-Resistant Major Depressive Disorder; Evidence-based pharmacological approaches for treatment-resistant bipolar disorder; Psychosocial management of treatment-resistant mood disorders: current evidence; Electroconvulsive therapy for treatment-resistant mood disorders; Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders; Vagus Nerve Stimulation and Deep Brain Stimulation: Implantable Device-Related Neurostimulation for Treatment-Resistant Mood Disorders; Novel Therapeutic Targets for Major Depressive Disorder; Novel therapeutic targets for bipolar disorder;
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