Cholera, which is caused by pathogenic strains of Vibrio cholerae, continues to threaten public health and socio-economic development in many developing countries, particularly those that lack access to potable water and adequate sanitation. The emergence of new V. cholerae strains and the severity of recent cholera outbreaks that began in August 2008 in Zimbabwe, coupled with climate change and elevated antimicrobial resistance, highlighted the dynamics of cholera. For these reasons, cholera was placed at the forefront of world public health agenda. This book discusses the recent cholera outbreaks in Africa, with particular emphasis on the causes, epidemiology, virulence factors, diagnosis, treatment and possible methods of curbing V. cholerae-induced epidemics in the future.
Introduction; Cholera Situation in Africa from 2004 to 2008; Horizontal Gene Transfer & Virulence Factors of V. Cholerae; Causes and Predisposing Factors for Cholera Dynamics; Biological Factors; Climate Variations; Laboratory Diagnosis of Cholera; Phenotypic Methods; Immunological Assays:: Serotyping; Molecular Characterization; Culture-Independent Identification of V. Cholerae; Strategies to Curb Widespread Cholera Transmission; Simple Ways for Water Treatment in Africa; Oral Cholera Vaccines; Management of Human Migration; Remote Sensing for Monitoring Cholera; Conclusion; Index.
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