Hans Krebs

This comprehensive volume completes Frederic Holmess notable and detailed biography of Hans Krebs, from the investigators early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebss research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and ofthe scientific process as a whole. The first volume, published in 1991, covered Krebss formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs,from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known—the formulation of the citric acid cycle. Holmes portrays Krebss activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmess fascinating portrait of Krebs integrates the great scientists investigative pathways with his personal life. The result is an illuminating analysis ofboth man and scientist that will be of interest to biochemists and historians of science.