Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy. The book highlights why it is important that all practicing pharmacists, including those working in hospitals or high street stores, have a solid understanding of the process of the design and development of the drugs they interact with. It adopts an integrated approach, formulated to complement courses which are designed in line with the General Pharmaceutical Councils new curriculum requirements. Furthermore, this is the only integrated textbook to consider both drug design and development within one volume. Throughout the book, the journey of the drug, from discovery to market, is presented in an integrated fashion, emphasising the interconnection of all the processes involved.
Introduction; Part 1 Drug targets; Receptors and signal transduction; Enzymes as drug targets; Nucleic acids and protein synthesis as drug targets; Other drug targets; Part 2 Origins of drug molecules; Sources of lead compounds; Drug synthesis; Optimisation of lead compounds; Computer-aided drug design; Combinatorial chemistry and high-throughput screening; Biotechnology and biopharmaceuticals; Part 3 Biological aspects of drug development; Drug metabolism; Pharmacogenetics and pharmacogenomics; Toxicity testing; Part 4 Preformulation studies; Solubility and drug development; Solid state characteristics; Drug stability; Part 5 Clinical research; Clinical research and its regulation; Design and management of clinical trials;
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