The most trusted and up-to-date pharmacology text in medicine - completely redesigned to make the learning process even more interesting and efficient. Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field?s most current, authoritative, and comprehensive textbook. To be as clinically relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects.
Coverage that spans every important aspect of medical pharmacology::
• Basic Principles • Autonomic Drugs • Cardiovascular-Renal Drugs • Drugs with Important Actions on Smooth Muscle • Drugs that Act in the Central Nervous System • Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout • Endocrine Drugs • Chemotherapeutic Drugs • Toxicology
NEW to this edition::
• Full-color presentation, including 300+ illustrations • Case studies introduce clinical problems in many chapters • Drug summary tables for key information in comparative context • Descriptions of important newly released drugs, including new immunopharmacologic agents • Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters
I. BASIC PRINCIPLES 1. Introduction 2. Drug Receptors & Pharmacodynamics 3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Tiem Course of Drug Action 4. Drug Biotransformation 5. Basic & Clinical Evaluation of New Drugs
II. AUTONOMIC DRUGS 6. Introduction to Autonomic Pharmacology 7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs 8. Cholinoceptor-Blocking Drugs 9. Adrenoceptor-Activating & Other Sympathomimetic Drugs 10. Adrenoceptor Antagonist Drugs
III. CARDIOVASCULAR-RENAL DRUGS 11. Antihypertensive Agents 12. Vasodilators & the Treatment of Angina Pectoris 13. Drugs Used in Heart Failure 14. Agents Used in Cardiac Arrhythmias 15. Diuretic Agents
IV. DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 16. Histamine, Serotonin, & the Ergot Alkaloids 17. Vasoactive Peptides 18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds 19. Nitric Oxide, Donors, & Inhibitors 20. Drugs Used in Asthma
V. DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 21. Introduction to the Pharmacology of CNS Drugs 22. Sedative-Hypnotic Drugs 23. The Alcohols 24. Antiseizure Drugs 25. General Anesthetics 26. Local Anesthetics 27. Skeletal Muscle Relaxants 28. Pharmacologic Management of Parkinsonism & Other Movement Disorders 29. Antipsychotic Agents & Lithium 30. Antidepressant Agents 31. Opioid Analgesics & Antagonists 32. Drugs of Abuse
VI. DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT 33. Agents Used in Anemias; Hematopoietic Growth Factors 34. Drugs Used in Disorders of Coagulation 35. Agents Used in Hyperlipidemia 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout
VII: ENDOCRINE DRUGS 37. Hypothalamic & Pituitary Hormones 38. Thyroid & Antithyroid Drugs 39. Adrenocorticosteroids & Adrenocortical Antagonists 40. The Gonadal Hormones & Inhibitors 41. Pancreatic Hormones & Antidiabetic Drugs 42. Agents That Affect Bone Mineral Homeostasis
VIII: CHEMOTHERAPEUTIC DRUGS 43. Beta-Lactam Antibodies & Other Inhibitors of Cell Wall Synthesis 44. Chloramphenicol. Tetracyclines, Macrolides, Clindamycin, & Streptogramins 45. Aminoglycosides & Spectinomycin 46. Sulfonamides, Trimethoprim, & Quinolones 47. Antimycobacterial Drugs 48. Antifungal Drugs 49. Antiviral Agents 50. Miscellaneous Antimicrobial Drugs: Disinfectants, Antiseptics, & Sterilants 51. Clinical Use of Antimicrobial Agents 52. Basic Principles of Antiparasitic Chemotherapy 53. Antiprotozoal Drugs 54. Clinical Pharmacology of the Anthelmintic Drugs 55. Cancer Chemotherapy 56. Immunopharmacology
IX. TOXICOLOGY 57. Introduction to Toxicology: Occupational & Environmental 58. Heavy Metal Intoxication & Chelators 59. Management of the Poisoned Patient
X. SPECIAL TOPICS 60. Special Aspects of Perinatal & Pediatric Pharmacology 61. Special Aspects of Geriatric Pharmacology 62. Dermatologic Pharmacology 63. Drugs Used in Gastrointestinal Diseases 64. Therapeutic & Toxic Potential of Over-the-Counter Agents, Botanicals, and Nutritional Supplements Appendix I. Vaccines, Immune Globulins, & Other Complex Biologic Products