The current science of pharmacology-and its clinical applications-at your fingertips Now in its 25th year of publication, Basic and Clinical Pharmacology is the most up-to-date and complete pharmacology textbook available. Through nine previous editions it has set the standard for concise and easy-to-read, yet comprehensive coverage of pharmacology. The texts integration of basic with clinical science makes it well suited for an integrated organ-system-based curricula as well as the more traditional curricula. Features - In-depth coverage of key pharmacology topics, from basic principles to pharmacologic considerations for autonomic, cardiovascular-renal, smooth muscle, CNS, endocrine, antimicrobial, and chemotherapeutic and immunotherapeutic drugs - Updated with dozens of new, recently approved drugs, including monoclonal antibodies - Detailed review of the mechanism of action and toxicities of traditional and newer drugs - Critical discussions of treatment strategies and recommended drugs for all major diseases - Valuable section on toxicology that provides an introduction to occupational and environmental toxicology; heavy metal intoxication and chelators; and management of the poisoned patient - Ready-to-use, study-enhancing features, including special interest boxes, lists of common preparations, and dosage information - Unique evidence-based chapters on abused drugs; special aspects of perinatal, pediatric, and geriatric pharmacology; and over-the-counter drugs, herbal medications, and nutritional supplements - More than 500 concept-clarifying illustrations and tables throughout
I. BASIC PRINCIPLES 1. Introduction 2. Drug Receptors & Pharmacodynamics 3. Pharmacokinetics & Pharmacodynamics:: Rational Dosing & the Tiem Course of Drug Action 4. Drug Biotransformation 5. Basic & Clinical Evaluation of New Drugs
II. AUTONOMIC DRUGS 6. Introduction to Autonomic Pharmacology 7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs 8. Cholinoceptor-Blocking Drugs 9. Adrenoceptor-Activating & Other Sympathomimetic Drugs 10. Adrenoceptor Antagonist Drugs
III. CARDIOVASCULAR-RENAL DRUGS 11. Antihypertensive Agents 12. Vasodilators & the Treatment of Angina Pectoris 13. Drugs Used in Heart Failure 14. Agents Used in Cardiac Arrhythmias 15. Diuretic Agents
IV. DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 16. Histamine, Serotonin, & the Ergot Alkaloids 17. Vasoactive Peptides 18. The Eicosanoids:: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds 19. Nitric Oxide, Donors, & Inhibitors 20. Drugs Used in Asthma
V. DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 21. Introduction to the Pharmacology of CNS Drugs 22. Sedative-Hypnotic Drugs 23. The Alcohols 24. Antiseizure Drugs 25. General Anesthetics 26. Local Anesthetics 27. Skeletal Muscle Relaxants 28. Pharmacologic Management of Parkinsonism & Other Movement Disorders 29. Antipsychotic Agents & Lithium 30. Antidepressant Agents 31. Opioid Analgesics & Antagonists 32. Drugs of Abuse
VI. DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT 33. Agents Used in Anemias; Hematopoietic Growth Factors 34. Drugs Used in Disorders of Coagulation 35. Agents Used in Hyperlipidemia 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout
VII:: ENDOCRINE DRUGS 37. Hypothalamic & Pituitary Hormones 38. Thyroid & Antithyroid Drugs 39. Adrenocorticosteroids & Adrenocortical Antagonists 40. The Gonadal Hormones & Inhibitors 41. Pancreatic Hormones & Antidiabetic Drugs 42. Agents That Affect Bone Mineral Homeostasis
VIII:: CHEMOTHERAPEUTIC DRUGS 43. Beta-Lactam Antibodies & Other Inhibitors of Cell Wall Synthesis 44. Chloramphenicol. Tetracyclines, Macrolides, Clindamycin, & Streptogramins 45. Aminoglycosides & Spectinomycin 46. Sulfonamides, Trimethoprim, & Quinolones 47. Antimycobacterial Drugs 48. Antifungal Drugs 49. Antiviral Agents 50. Miscellaneous Antimicrobial Drugs:: Disinfectants, Antiseptics, & Sterilants 51. Clinical Use of Antimicrobial Agents 52. Basic Principles of Antiparasitic Chemotherapy 53. Antiprotozoal Drugs 54. Clinical Pharmacology of the Anthelmintic Drugs 55. Cancer Chemotherapy 56. Immunopharmacology
IX. TOXICOLOGY 57. Introduction to Toxicology:: Occupational & Environmental 58. Heavy Metal Intoxication & Chelators 59. Management of the Poisoned Patient
X. SPECIAL TOPICS 60. Special Aspects of Perinatal & Pediatric Pharmacology 61. Special Aspects of Geriatric Pharmacology 62. Dermatologic Pharmacology 63. Drugs Used in Gastrointestinal Diseases 64. Therapeutic & Toxic Potential of Over-the-Counter Agents, Botanicals, and Nutritional Supplements Appendix I. Vaccines, Immune Globulins, & Other Complex Biologic Products
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