In this issue of Clinics in Perinatology, guest editors Drs. Jonathan M. Davis and Errol R. Norwitz bring their considerable expertise to the topic of Perinatal Pharmacology. Top experts offer comprehensive, evidence-based insights into key topics pertaining to drug safety, efficacy, and pharmacokinetics in pregnancy, labor, and the immediate postnatal period, with the goal of improving maternal-fetal outcomes, minimizing risks, and enhancing treatment strategies for some of the most vulnerable patients in medicine.