Fetal and Neonatal Physiology, 2-Volume Set

• Section I - Genetics and Embryology

• Basic Genetic Principles

Prenatal Diagnosis

Basic Embryology

Regulation of Embryogenesis

The Extracellular Matrix in Development

Stem Cell Biology

Apoptotic Cell Death

Angiogenesis

Epigenetics

Section II - Placenta and Intrauterine Environment

Placental Development

Regulation of the Placental Circulation

Mechanisms of Transfer Across the Human Placenta

Endocrine and Paracrine Function of the Human Placenta

Fetal and Maternal Responses to Intrauterine Infection

Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance

Physiologic Effects of Multiple Pregnancy on Mother and Fetus

Placental function in intrauterine growth restriction

Section III - Developmental Pharmacology and Pharmacokinetics

Basic Pharmacologic Principles

Principles of Pharmacokinetics

Physicochemical and Structural Properties Regulating Placental Drug Transfer

Pharmacogenetics

Drug Distribution in Fetal Life

Drug Transfer During Breastfeeding

Section IV - Intrauterine and Postnatal Growth

Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction

Endocrine Factors Affecting Neonatal Growth

Human Milk Composition and Function in the Infant

Physiology of Lactation

Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

Fetal and Neonatal Iron Metabolism

Neonatal Calcium, Phosphorus, and Magnesium Homeostasis

Zinc in the Fetus and Neonate

Vitamin A Metabolism in the Fetus and Neonate

Vitamin E Metabolism in the Fetus and Newborn Infant

Vitamin K Metabolism in the Fetus and Neonate

Section VI - Lipid Metabolism

Maternal-Fetal Transfer of Lipid Metabolites

Brown Adipose Tissue: Development and Function

Lipids as an Energy Source for the Premature and Full-Term Neonate

Ketone Body Production and Metabolism in the Fetus and Neonate

Long-Chain Fatty Acids in the Developing Retina and Brain

Section VII - Carbohydrate Metabolism

Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn

Carbohydrate Metabolism During Pregnancy

Oxygen Consumption and General Carbohydrate Metabolism of the Fetus

Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period

Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Section VIII - Protein Metabolism

General Concepts of Protein Metabolism

Fetal Requirements and Placental Transfer of Nitrogenous Compounds

Section IX - Thermoregulation

Temperature Control in Newborn Infants

Responses of the Fetus and Neonate to Hypothermia

Section X - Skin

Structure and Development of Skin and Cutaneous Appendages

Physiologic Development of the Skin

Section XI - Fetal and Neonatal Cardiovascular Physiology

Cardiovascular Development

Developmental Electrophysiology in the Fetus and Neonate

Developmental Biology of the Pulmonary Vasculature

Development of the Gastrointestinal Circulation in the Fetus and Newborn

Physiology of Congenital Heart Disease in the Neonate

Neural Regulation of Blood Pressure During Fetal and Newborn Life

Developmental Effects on Fetal Circulation

Mechanisms Regulating Closure of the Ductus Arteriosus

Umbilical Circulation

Fetal and Placental Circulation During Labor

Physiology of Resuscitation

Section XII - The Lung

Normal and Abnormal Structural Development of the Lung

Regulation of Alveolarization

Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth

Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis

Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung

Upper Airway Structure: Function, Regulation, and Development

Regulation of Lower Airway Function

Functional Development of Respiratory Muscles

Mechanics of Breathing

Pulmonary Gas Exchange in the Developing Lung

Oxygen Transport and Delivery

Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate

Basic Mechanisms of Oxygen Sensing and Response to Hypoxia

Evaluation of Pulmonary Function in the Neonate

Mechanisms of Neonatal Lung Injury

Impaired Lung Growth After Injury in Premature Lung

Antenatal Factors That Influence Postnatal Lung Development and Injury

Regulation of Pulmonary Circulation

Section XIII - Surfactant

Historical Perspective

Composition of Pulmonary Surfactant Lipids and Proteins

Structure And Development of Alveolar Epithelial Cells

Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion

Hormonal Therapy for Prevention of Respiratory Distress Syndrome

Surfactant Treatment

Genetics and Physiology of Surfactant Protein Deficiencies

Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate

Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development

Organogenesis of the Gastrointestinal Tract

Development of the Enteric Nervous System

Development of Gastric Secretory Function

Development of Gastrointestinal Motility

Development of the Exocrine Pancreas

Digestive-Absorption Functions in Fetuses, Infants, and Children

Development of the Intestinal Microbiome

Section XV - Liver and Bilirubin Metabolism

Organogenesis and Histologic Development of the Liver

Bile Acid Metabolism During Development

Neonatal Bilirubin Metabolism

Hereditary Contribution to Neonatal Hyperbilirubinemia

Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia

Section XVI - The Kidney

Embryogenesis and Anatomic Development of the Kidney

Functional Development of the Kidney in Utero

Development and Regulation of Renal Blood flow in the Neonate

Development of the Renin-Angiotensin System

Postnatal Development of Glomerular Filtration Rate in Neonates

Renal Transport of Sodium During Early Development

Potassium Homeostasis in the Fetus and Neonate

Role of the Kidney in Calcium and Phosphorus Homeostasis

Transport of Amino Acids in the Fetus and Neonate

Developmental Aspects of Organic Acid Transport

Concentration and Dilution of the Urine

Development of Acidification Mechanisms in the Fetus and Neonate

Response to Nephron Loss in Early Development

Section XVII - Fluid and Electrolyte Metabolism

Fluid Distribution in the Fetus and Neonate

Regulation of Acid-Base Balance in the Fetus and Neonate

Section XVIII - Developmental Hematopoiesis

Developmental Biology of Stem Cells: From the Embryo to the Adult

Developmental Granulocytopoiesis

Developmental Erythropoiesis

Developmental Megakaryocytopoiesis

Section XIX - Hemostasis

Developmental Hemostasis

Platelet-Vessel Wall Interactions

Section XX - Developmental Immunobiology

Host Defense Mechanisms Against Bacteria

Host-Fungi Interactions Relevant to the Newborn Infant

Host Defense Mechanisms Against Viruses

T-Cell Development

B-Cell Development

Mononuclear Phagocyte System

Normal and Abnormal Neutrophil Physiology in the Newborn

The Complement System of the Fetus and Newborn

Cytokines and Inflammatory Response in the Fetus and Neonate

Immunology of Human Milk and Host Immunity

Neonatal Pulmonary Host Defense

Section XXI - Neurology

Development of the Nervous System

Development of the Blood-Brain Barrier

Trophic Factor and Nutritional and Hormonal Regulation of Brain Development

Intraventricular Hemorrhage in the Neonate

Cerebellar Development - an Impact of Preterm Birth and Co-Morbidities

Electroencephalography in the Premature and Full-Term Infant

Developmental Aspects of Pain

Section XXII - Special Sensory Systems in the Fetus and Neonate

Early Development of the Human Auditory System

Development of Taste and Smell in the Neonate

Section XXIII - Orthopedics

The Growth Plate: Embryologic Origin, Structure, and Function

Ontogenesis of Striated Muscle

Section XXIV - Endocrine Function

Hypothalamus: Neuroendometabolic Center

Growth Factor Regulation of Fetal Growth

Growth Hormone in the Fetus and Newborn

Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn

Development of the Corticotropin-Releasing Hormone-Corticotropin System in the Mammalian Fetus

Fetal and Neonatal Adrenocortical Physiology

Fetal and Neonatal Thyroid Physiology

Section XXV - Ovary and Testis

Genetics of Sex Determination and Differentiation

Differentiation of the Ovary

Testicular Development and Descent

Section XXVI - Pathophysiology of Neonatal Diseases

Pathophysiology of Neonatal sepsis

Pathophysiology of Hypoglycemia in the Neonate

Pathophysiology of Cardiomyopathies

Pathophysiology of Persistent pulmonary hypertension of the newborn

Pathophysiology of Shock in the Fetus and Neonate

Pathophysiology of Apnea of Prematurity

Pathophysiology of Respiratory Distress Syndrome

Pathophysiology of Meconium Aspiration Syndrome

Pathophysiology of Bronchopulmonary Dysplasia

Pathophysiology of Ventilator Dependent Infants

Pathophysiology of Gastroesophageal Reflux

Pathophysiology of Neonatal Necrotizing Enterocolitis

Pathophysiology of Kernicterus

Pathophysiology of neonatal acute kidney injury

Pathophysiology of Edema

Pathophysiology of Retinopathy of Prematurity

Pathophysiology of Hypoxic-ischemic Brain Injury

Pathophysiology of Neonatal White Matter Injury

Pathophysiology of Meningitis

Pathophysiology of Neural Tube Defects

Pathophysiology of Preeclampsia

Pathophysiology of Preterm Birth

Pathophysiology of Chorioamnionitis