Avery's Diseases of the Newborn

P A R T I

Overview

Chapter 1 Neonatal and Perinatal

Epidemiology, 1

Chapter 2 Evaluation of Therapeutic

Recommendations, Database

Management, and Information

Retrieval, 10

Chapter 3 Ethics, Data, and Policy in

Newborn Intensive Care, 18

Chapter 4 Global Neonatal Health, 23

P A R T II

Fetal Development

Chapter 5 Immunologic Basis of Placental

Function and Diseases: The

Placenta, Fetal Membranes, and

Umbilical Cord, 37

Chapter 6 Abnormalities of Fetal

Growth, 51

Chapter 7 Multiple Gestations and Assisted

Reproductive Technology, 60

Chapter 8 Nonimmune Hydrops, 67

P A R T III

Maternal Health Affecting Neonatal

Outcome

Chapter 9 Endocrine Disorders in

Pregnancy, 75

Chapter 10 Maternal Medical Disorders of

Fetal Significance: Seizure Disorders,

Isoimmunization, Cancer,

and Mental Health Disorders, 92

Chapter 11 Hypertensive Complications of

Pregnancy, 105

Chapter 12 Perinatal Substance Abuse, 111

P A R T IV

Labor and Delivery

Chapter 13 Antepartum Fetal Assessment, 129

Chapter 14 Prematurity: Causes and

Prevention, 140

Chapter 15 Complicated Deliveries:

Overview, 146

Chapter 16 Obstetric Analgesia and

Anesthesia, 159

P A R T V

Genetics

Chapter 17 Impact of the Human Genome

Project on Neonatal Care, 173

Chapter 18 Prenatal Genetic Diagnosis, 180

Diana W. Bianchi

Chapter 19 Evaluation of the Dysmorphic

Infant, 186

Chapter 20 Specific Chromosome Disorders

in Newborns, 196

P A R T VI

Metabolic and Endocrine Disorders

of the Newborn

Chapter 21 Introduction to Metabolic and

Biochemical Genetic Disease, 209

CONTENTS

xviii CONTENTSChapter 22 Inborn Errors of Carbohydrate,

Ammonia, Amino Acid, and

Organic Acid Metabolism, 215

Chapter 23 Lysosomal Storage, Peroxisomal,

and Glycosylation Disorders

and Smith-Lemli-Opitz Syndrome

in the Neonate, 239

Chapter 24 Skeletal Dysplasias and

Connective Tissue Disorders, 258

P A R T VII

Care of the Healthy Newborn

Chapter 25 Initial Evaluation: History and

Physical Examination of the

Newborn, 277

Chapter 26 Routine Newborn Care, 300

Chapter 27 Newborn Screening, 316

Chapter 28 Resuscitation in the Delivery

Room, 328

P A R T VIII

Care of the High-Risk Infant

Chapter 29 Stabilization and Transport

of the High-Risk Infant, 341

Chapter 30 Temperature Regulation of the

Premature Neonate, 357

Chapter 31 Acid-Base, Fluid, and Electrolyte

Management, 367

Chapter 32 Care of the Extremely Low-

Birthweight Infant, 390

Chapter 33 Care of the Late Preterm

Infant, 405

Chapter 34 Pharmacokinetics,

Pharmacodynamics,

and Pharmacogenetics, 417

Chapter 35 Neonatal Pain and Stress:

Assessment and Management, 429

P A R T IX

Immunology and Infections

Chapter 36 Immunology of the Fetus

and Newborn, 445

Chapter 37 Viral Infections of the Fetus and

Newborn and Human Immunodeficiency Virus

Infection During Pregnancy, 468

Chapter 38 Toxoplasmosis, Syphilis, Malaria,

and Tuberculosis, 513

Chapter 39 Neonatal Bacterial Sepsis, 538

Chapter 40 Health Care - Acquired Infections

in the Nursery, 551

Chapter 41 Fungal Infections in the

Neonatal Intensive Care Unit, 565

P A R T X

Respiratory System

Chapter 42 Lung Development: Embryology,

Growth, Maturation,

and Developmental Biology, 571

Maria Victoria Fraga ? Susan Guttentag

Chapter 43 Control of Breathing, 584

Estelle B. Gauda ? Richard J. Martin

Chapter 44 Pulmonary Physiology

of the Newborn, 598

Chapter 45 Principles of Respiratory

Monitoring and Therapy, 612

Chapter 46 Respiratory Distress

in the Preterm Infant, 633

Chapter 47 Respiratory Failure in the Term

Newborn, 647

Chapter 48 Bronchopulmonary Dysplasia, 658

Chapter 49 Surgical Disorders of the Chest

and Airways, 672CONTENTS xix

P A R T XI

Cardiovascular System

Chapter 50 Embryology and Physiology

of the Cardiovascular System, 699

Chapter 51 Cardiovascular Compromise

in the Newborn Infant, 714

Chapter 52 Persistent Pulmonary

Hypertension, 732

Chapter 53 Fetal and Neonatal

Echocardiography, 741

Chapter 54 Patent Ductus Arteriosus

in the Preterm Infant, 751

Chapter 55 Congenital Heart Disease, 762

Chapter 56 Arrhythmias in the Fetus

and Newborn, 789

Chapter 57 Neurodevelopmental Outcomes

in Children with Congenital

Heart Disease, 801

P A R T XII

Neurologic System

Chapter 58 Developmental Physiology of

the Central Nervous

System, 811

Chapter 59 Neonatal Neuroimaging, 816

Chapter 60 Congenital Malformations

of the Central Nervous

System, 844

Chapter 61 Central Nervous System Injury

and Neuroprotection, 869

Chapter 62 Neonatal Neuromuscular

Disorders, 892

Chapter 63 Neonatal Seizures, 901

Chapter 64 Risk Assessment and

Neurodevelopmental

Outcomes, 920

P A R T XIII

Nutrition

Chapter 65 Breastfeeding, 937

Chapter 66 Enteral Nutrition for the

High-Risk Neonate, 952

Chapter 67 Parenteral Nutrition, 963

P A R T XIV

Gastrointestinal System

Chapter 68 Developmental Anatomy

and Physiology of the

Gastrointestinal Tract, 973

Chapter 69 Structural Anomalies of the

Gastrointestinal Tract, 979

Chapter 70 Innate and Mucosal Immunity in

the Developing Gastrointestinal

Tract: Relationship to Early and

Later Disease, 994

Chapter 71 Abdominal Wall Problems, 1007

Chapter 72 The Developing Intestinal

Microbiome: Implications

for the Neonate, 1016

Chapter 73 Necrotizing Enterocolitis

and Short Bowel Syndrome, 1022

Chapter 74 Disorders of the Liver, 1030

P A R T XV

Hematologic System and Disorders

of Bilirubin Metabolism

Chapter 75 Developmental Biology of the

Hematologic System, 1047

Chapter 76 Hemostatic Disorders of the

Newborn, 1056

Chapter 77 Erythrocyte Disorders in

Infancy, 1080CONTENTSChapter 78 Neonatal Leukocyte Physiology

and Disorders, 1108

Chapter 79 Neonatal Indirect

Hyperbilirubinemia and

Kernicterus, 1123

P A R T XVI

Neoplasia

Chapter 80 Congenital Malignant

Disorders, 1143

P A R T XVII

Renal and Genitourinary Systems

Chapter 81 Renal Morphogenesis and

Development of Renal

Function, 1165

Chapter 82 Clinical Evaluation of Renal and

Urinary Tract Disease, 1176

Chapter 83 Developmental Abnormalities of

the Kidneys, 1182

Chapter 84 Developmental Abnormalities of

the Genitourinary System, 1191

Chapter 85 Acute Kidney Injury and Chronic

Kidney Disease, 1205

Chapter 86 Glomerulonephropathies

and Disorders of Tubular

Function, 1222

Chapter 87 Urinary Tract Infections and

Vesicoureteral Reflux, 1228

Chapter 88 Renal Vascular Disease in the

Newborn, 1235

P A R T XVIII

Endocrine Disorders

Chapter 89 Embryology, Developmental

Biology, and Anatomy of the

Endocrine System, 1245

Chapter 90 Disorders of Calcium and

Phosphorus Metabolism, 1255

Chapter 91 Disorders of the Adrenal

Gland, 1274

Chapter 92 Ambiguous Genitalia in the

Newborn, 1286

Chapter 93 Disorders of the Thyroid

Gland, 1307

Chapter 94 Disorders of Carbohydrate

Metabolism, 1320

P A R T XIX

Craniofacial and Orthopedic

Conditions

Chapter 95 Craniofacial

Malformations, 1331

Chapter 96 Common Neonatal Orthopedic

Ailments, 1351

P A R T XX

Dermatologic Conditions

Chapter 97 Newborn Skin: Development

and Basic Concepts, 1363

Chapter 98 Congenital and Hereditary

Disorders of the Skin, 1373

Chapter 99 Infections of the Skin, 1390

Chapter 100 Common Newborn

Dermatoses, 1397

Chapter 101 Cutaneous Congenital

Defects, 1406

P A R T XXI

The Eye

Chapter 102 Disorders of the Eye, 1423