In this issue of Pediatric Clinics of North America, guest editor Dr. Danielle Laraque-Arena brings her considerable expertise to the topic of Imperatives for Action and Impact of Humanitarian Crises Affecting Children. Beginning with a framing of child rights and the necessary global response from humanitarian voices, the discourse is anchored on the concepts of global organizational capacity, clinical capabilities, and advocacy for children, their families, and communities. This issue brings not only renewed awareness of the grand scale of crises globally affecting children, but puts forth a call for action by pediatricians and the world community at large to reduce the unimaginable scale of harm to children.