In this issue of Pediatric Clinics of North America, guest editors Drs. Maya Ragavan and Abby Nerlinger bring their considerable expertise to the topic of Climate Change and Children. Climate change is the most pressing public health threat of the century, with significant impacts on child health and well-being. In this issue, top experts provide a framework for pediatric providers to increase knowledge, provide strategies, and take action to address climate change and improve health and well-being for children.