In this issue of Pediatric Clinics of North America, guest editors Drs. Lois K. Lee and Flaura K. Winston bring their considerable expertise to the topic of Preventing Unintentional Injuries among Children and Youth. Unintentional injuries continue to be a leading cause of mortality and morbidity among U.S. children and youth and globally, and there are also important health disparities related to socio-economic inequities in different populations of children. In this issue, top experts discuss key topics such as pediatric considerations for home safety and water safety, consumer product injuries in children, child passenger and teen driving safety, injury prevention technology, and much more.