In this issue of Gastroenterology Clinics, guest editors Drs. Carlo DiLorenzo and Peter L. Lu bring their considerable expertise to the topic of Present and Future of Pediatric Neurogastroenterology and Motility. Disorders of gut-brain interaction and diseases of gastrointestinal motility are highly prevalent in children and have a considerable impact on the quality of life of affected individuals. In this issue, top experts review several disorders where our understanding of pathophysiology and management has been recently expanding, and also discuss the future of the field of pediatric neurogastroenterology.