In this issue of Clinics in Laboratory Medicine, guest editor Dr. Octavia M. Peck Palmer brings her considerable expertise to the topic of Centering Health Equity, Diversity, and Inclusion in Clinical Pathology. Top experts define health equity, discuss its importance, and describe the role of laboratory medicine in ensuring health equity through providing accessible and accurate clinical testing, clinically appropriate reference intervals, and culturally safe interpretative comments that meet the needs of the patient populations it serves. This issue also covers how clinical labs can conduct clinical trials, utilize residual specimens, and establish virtual biobanks that enroll individuals that are age, gender, ethnic/racial, and geographically diverse to ensure representation.