Diagnostic Pathology: Cytopathology

Part I: Gynecologic Cytopathology SECTION 1: OVERVIEW

4 Pap Test and Cervical Cancer Screening: History and Reporting Terminology Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 8 Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology Michael J. Thrall, MD and Debora A. Smith, CT(ASCP) 10 Specimen Adequacy in Cervicovaginal Cytology Dina R. Mody, MD and George G. Birdsong, MD

SECTION 2: BENIGN AND INFECTIOUS CONDITIONS

14 Normal Pap Test Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 16 Infectious and Other Organisms in Pap Tests Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 18 Nonneoplastic Findings, Mimics, and Artifacts Ekene I. Okoye, MD and Dina R. Mody, MD

SECTION 3: SQUAMOUS CELLABNORMALITIES AND MIMICS

28 Low-Grade Squamous Intraepithelial Lesion and Mimics Dina R. Mody, MD 30 High-Grade Squamous Intraepithelial Lesion and Mimics Dina R. Mody, MD and Ekene I. Okoye, MD 34 Atypical Squamous Cells of Undetermined Significance Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 36 Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion Dina R. Mody, MD and Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC 38 Squamous Cell Carcinoma of Cervix, Variants and Mimics Dina R. Mody, MD

46 Endocervical Adenocarcinoma In Situ, Variants and Mimics Dina R. Mody, MD 52 Endocervical Adenocarcinoma, Variants and Mimics Dina R. Mody, MD 56 Adenocarcinoma, Gastric Type Dina R. Mody, MD 58 Endometrial Cancers: Usual Types, Variants, and Mimics Ekene I. Okoye, MD and Dina R. Mody, MD 64 Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS Dina R. Mody, MD 70 Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy Dina R. Mody, MD and Ekene I. Okoye, MD

74  Extrauterine Carcinomas and Presentations in  Cervicovaginal Cytology  Dina R. Mody, MD  76  Neuroendocrine Carcinoma of Cervix  Dina R. Mody, MD  78  Other Uncommon Malignancies in Cervicovaginal  Cytology  Dina R. Mody, MD 

84 HPV and Other Molecular Testing in Gynecologic Cytology Michael J. Thrall, MD

90 Directly Sampled Endometrial Cytology Yuko Sugiyama, MD, PhD, FIAC and Dina R. Mody, MD

96 Anal Cytology Michael J. Thrall, MD

Part II: Exfoliative Cytopathology

Specimen Types in Respiratory Cytology and Adequacy Criteria Michael J. Thrall, MD 102 Benign and Reactive Changes Michael J. Thrall, MD 106 PneumocystisPneumonia and Mimics Michael J. Thrall, MD 108 Fungal Organisms in Respiratory Cytology Michael J. Thrall, MD Parasitic Organisms in Respiratory Cytology Michael J. Thrall, MD 112 Viral Infections (Cytomegalovirus, Herpesvirus, and Others) Michael J. Thrall, MD 114 Mycobacteria and Other Bacterial Infections Michael J. Thrall, MD 116 Sarcoidosis and Other Immune-Related Conditions Michael J. Thrall, MD 118 Pulmonary Alveolar Proteinosis and Mimics Michael J. Thrall, MD Miscellaneous Findings, Including Contaminants Michael J. Thrall, MD 122 Adenocarcinoma Michael J. Thrall, MD 126 Squamous Cell Carcinoma Michael J. Thrall, MD 128 Small Cell Carcinoma Michael J. Thrall, MD Large Cell Neuroendocrine Carcinoma Michael J. Thrall, MD 132 Carcinoid and Atypical Carcinoid Michael J. Thrall, MD 134 Rare Benign and Low Malignant Potential Tumors Michael J. Thrall, MD 136 Rare Malignant Tumors Michael J. Thrall, MD 138 NUT Carcinoma Michael J. Thrall, MD 139 SMARCA4-Deficient Undifferentiated Tumor Michael J. Thrall, MD Pulmonary Lymphoma Michael J. Thrall, MD 142 Pulmonary Metastasis Michael J. Thrall, MD

146 Specimen Types in Gastrointestinal Cytology and Normal Cellular Components Blythe K. Gorman, MD 148 Parasitic Infections Blythe K. Gorman, MD Viral Infections Blythe K. Gorman, MD 152 Esophagitis and Barrett Esophagus Blythe K. Gorman, MD 154 Esophageal Adenocarcinoma Blythe K. Gorman, MD 156 Esophageal Squamous Cell Carcinoma Blythe K. Gorman, MD 158 Gastritis and Intestinal Metaplasia Blythe K. Gorman, MD Gastric Adenocarcinoma Blythe K. Gorman, MD 162 Gastric Lymphoma Blythe K. Gorman, MD 164 Ampulla/Bile Duct/Pancreatic Duct Reactive Changes Blythe K. Gorman, MD 166 Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma Blythe K. Gorman, MD 168 Colorectal Adenoma/Carcinoma Blythe K. Gorman, MD Neuroendocrine Tumor/Carcinoma Blythe K. Gorman, MD 172 Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors Blythe K. Gorman, MD

176 Normal Cerebrospinal Fluid and Contamination by Normal Elements Hidehiro Takei, MD Infectious Meningitis Hidehiro Takei, MD 182 Aseptic and Mollaret Meningitis Hidehiro Takei, MD 184 Subarachnoid Hemorrhage Hidehiro Takei, MD 186 Neurodegenerative Diseases Hidehiro Takei, MD 188 Primary Brain Tumors Hidehiro Takei, MD Leukemia and Lymphoma Hidehiro Takei, MD 192 Metastasis in Cerebrospinal Fluid Hidehiro Takei, MD

196 Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology Donna M. Coffey, MD and Michael J. Thrall, MD Infectious Conditions Donna M. Coffey, MD and Michael J. Thrall, MD 202 Autoimmune Diseases Donna M. Coffey, MD and Michael J. Thrall, MD 204 Malignant Effusion, Mesothelioma 208 Malignant Effusion, Carcinomas 212 Malignant Effusion, Sarcomas

Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

214 Lymphoid Effusions and Lymphomas Donna M. Coffey, MD and Michael J. Thrall, MD

216 Primary Effusion Lymphoma John M. Stewart, MD, PhD and Michael J. Thrall, MD

218 Endometriosis and Endosalpingiosis Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

220 Ovarian Neoplasms Donna M. Coffey, MD and Michael J. Thrall, MD

222 Immunocytochemistry, Histochemistry, and Other Ancillary Techniques Donna M. Coffey, MD and Michael J. Thrall, MD

228 Normal Urinary Cytology, Specimen Types, and Reporting Terminology Michael J. Thrall, MD and Rose Anton, MD

232 Ileal Conduit Specimens Rose Anton, MD and Michael J. Thrall, MD

234 Noninfectious Benign Conditions Rose Anton, MD and Michael J. Thrall, MD

236 Infectious Benign Conditions Rose Anton, MD and Michael J. Thrall, MD

238 Reactive Urothelial Changes Rose Anton, MD and Michael J. Thrall, MD

240 Low-Grade Urothelial Lesions Rose Anton, MD and Michael J. Thrall, MD

241 Atypical Urothelial Cells Michael J. Thrall, MD

242 High-Grade Urothelial Dysplasia/Carcinoma/Carcinoma In Situ Rose Anton, MD and Michael J. Thrall, MD

244 Squamous Cell Carcinoma of Urinary Bladder Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

246 Adenocarcinoma of Urinary Bladder Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

248 Other Malignancies in Urinary Cytology Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

250 Renal Pelvic Cytology Blythe K. Gorman, MD and Michael J. Thrall, MD

252 Ancillary Testing, UroVysion, and Others Gene Landon, MD, Nancy P. Caraway, MD, and Michael J. Thrall, MD

Part III: Fine-Needle Aspiration, Superficial

256 Superficial Aspiration Technique Rose Anton, MD and Dina R. Mody, MD

260 Ultrasound-Guided Thyroid Fine-Needle Aspiration Paula J. Woodward, MD 266 Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy Dina R. Mody, MD 268 Adenomatous (Benign Follicular) Nodule Mojgan Amrikachi, MD and Dina R. Mody, MD 270 Chronic Lymphocytic/Hashimoto Thyroiditis Mojgan Amrikachi, MD and Dina R. Mody, MD 272 Granulomatous Thyroiditis Mojgan Amrikachi, MD and Dina R. Mody, MD 274 Graves Disease/Diffuse Toxic Goiter Mukul K. Divatia, MD and Dina R. Mody, MD 275 Pigmented Thyroid Lesions and Crystals Mukul K. Divatia, MD and Dina R. Mody, MD 276 Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Dina R. Mody, MD 280 Follicular Neoplasm/Suspicious for a Follicular Neoplasm Dina R. Mody, MD 284 Follicular Neoplasm, Oncocytic (Hürthle Cell) Type Mojgan Amrikachi, MD and Dina R. Mody, MD 286 Papillary Thyroid Carcinoma, Classic Subtype Mojgan Amrikachi, MD and Dina R. Mody, MD 290 Papillary Thyroid Carcinoma Subtypes Mojgan Amrikachi, MD and Dina R. Mody, MD 298 Medullary Thyroid Carcinoma Mojgan Amrikachi, MD and Dina R. Mody, MD 302 Poorly Differentiated Thyroid Carcinoma Susan L. Haley, MD and Dina R. Mody, MD 304 Anaplastic Thyroid Carcinoma Susan L. Haley, MD and Dina R. Mody, MD 306 Thyroid Lymphoma Susan L. Haley, MD and Dina R. Mody, MD 308 Metastatic Carcinoma to Thyroid Susan L. Haley, MD and Dina R. Mody, MD 310 Other Nonneoplastic and Neoplastic Thyroid Lesions Encountered on Thyroid FNA Mojgan Amrikachi, MD and Dina R. Mody, MD

318 Parathyroid Cyst, Adenoma, and Carcinoma Susan L. Haley, MD, Rose Anton, MD, and Dina R. Mody, MD

OVERVIEW 324 Lymph Node Aspiration: Indications, Techniques, and Reporting Rose Anton, MD and Dina R. Mody, MD 326 FNA Sample Prep and Triage in Evaluating Suspected Lymphoma John M. Stewart, MD, PhD and Savitri Krishnamurthy, MD

BENIGN, INFECTIOUS, AND REACTIVE HYPERPLASIA 328 Inflammatory and Reactive Lymphoid Hyperplasia Rose Anton, MD and Savitri Krishnamurthy, MD

330 Granulomatous Lymphadenitis, Infectious and Sarcoid Rose Anton, MD and Savitri Krishnamurthy, MD

334 Rosai-Dorfman Disease Rose Anton, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

METASTATIC MALIGNANCIES 336 Metastatic Malignancies (Carcinoma, Melanoma) Rose Anton, MD and Dina R. Mody, MD

338 HPV-Positive Head and Neck Squamous Cell Carcinoma Mary R. Schwartz, MD and Dina R. Mody, MD

NODAL B-CELL LYMPHOMA 342 Small Lymphocytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 344 Lymphoplasmacytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 346 Mantle Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 348 Nodal Marginal Zone Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 350 Follicular Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 352 Burkitt Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 354 Large B-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD EXTRANODAL B-CELL LYMPHOMA 356 Plasmacytoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 358 Mediastinal Large B-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 360 Plasmablastic Lymphoma John M. Stewart, MD, PhD, Nancy P. Caraway, MD, and Savitri Krishnamurthy, MD T-CELL LYMPHOMA 362 Peripheral T-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 364 Mycosis Fungoides Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 366 Angioimmunoblastic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 368 ALK(+) Anaplastic Large Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 370 T-Cell Lymphoblastic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD HODGKIN LYMPHOMA 372 Nodular Lymphocyte-Predominant Hodgkin Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

374 Classic Hodgkin Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

OVERVIEW 378 Approach to Interpretation of Salivary Gland Aspiration Biopsies and Reporting Terminology (Milan System) Dina R. Mody, MD BENIGN LESIONS 382 Normal Salivary Gland and Sialadenitis on Aspiration Rose Anton, MD and Dina R. Mody, MD

384 Cysts Rose Anton, MD and Dina R. Mody, MD

386 Pleomorphic Adenoma Rose Anton, MD and Dina R. Mody, MD

388 Warthin Tumor Rose Anton, MD and Dina R. Mody, MD

390 Myoepithelioma Rose Anton, MD and Dina R. Mody, MD

391 Oncocytoma, Salivary Gland Dina R. Mody, MD

MALIGNANT NEOPLASMS 392 Adenoid Cystic Carcinoma Rose Anton, MD and Dina R. Mody, MD

394 Acinic Cell Carcinoma Rose Anton, MD and Dina R. Mody, MD

396 Mucoepidermoid Carcinoma Rose Anton, MD and Dina R. Mody, MD

398 Basaloid Neoplasms, Benign and Malignant Hidehiro Takei, MD and Dina R. Mody, MD

400 Carcinoma Ex Pleomorphic Adenoma Hidehiro Takei, MD

402 Adenocarcinoma, NOS 404 Polymorphous Adenocarcinoma

Hidehiro Takei, MD and Dina R. Mody, MD 406 Salivary Duct Carcinoma Hidehiro Takei, MD and Dina R. Mody, MD 408 Secretory Carcinoma Michael J. Thrall, MD 410 Myoepithelial Carcinoma Shubhada Kane, MD and Michael J. Thrall, MD 411 Cribriform Adenocarcinoma Shubhada Kane, MD and Michael J. Thrall, MD 412 Metastatic Carcinoma Hidehiro Takei, MD 414 Primary and Metastatic Nonepithelial Tumors Dina R. Mody, MD and Hidehiro Takei, MD

OVERVIEW

418 Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test Savitri Krishnamurthy, MD BENIGN BREAST LESIONS 420 Inflammatory and Granulomatous Conditions Savitri Krishnamurthy, MD 422 Fat Necrosis Savitri Krishnamurthy, MD

424 Nonproliferative and Proliferative Changes in Breast Savitri Krishnamurthy, MD 428 Radial Scar/Complex Sclerosing Lesion Savitri Krishnamurthy, MD 430 Gynecomastia Savitri Krishnamurthy, MD 432 Mucocele-Like Lesion Savitri Krishnamurthy, MD BENIGN NEOPLASMS 434 Fibroadenoma Savitri Krishnamurthy, MD 438 Granular Cell Tumor of Breast Savitri Krishnamurthy, MD 440 Papillary Neoplasms Savitri Krishnamurthy, MD 446 Myofibroblastoma, Mammary Savitri Krishnamurthy, MD MALIGNANT NEOPLASMS

448 Ductal Carcinoma and Variants of Invasive Mammary Carcinoma Savitri Krishnamurthy, MD 456 Lobular Carcinoma Savitri Krishnamurthy, MD 458 Phyllodes Tumor Savitri Krishnamurthy, MD 460 Angiosarcoma and Other Sarcomas Savitri Krishnamurthy, MD 464 Lymphomas and Metastatic Tumors Savitri Krishnamurthy, MD NIPPLE DISCHARGE 466 Cytology Specimens for Risk Assessment of Breast Cancer Savitri Krishnamurthy, MD

470 Cutaneous and Adnexal Cytology Mary R. Schwartz, MD and Dina R. Mody, MD

Part IV: Fine-Needle Aspiration, Deep Organs and Tissues

476 Techniques and Modalities of Deep Aspiration Biopsies Paula J. Woodward, MD and Ashraf Thabet, MD

OVERVIEW 482 Anatomic Compartments and Constituent Tumors Ming Guo, MD and Savitri Krishnamurthy, MD NONNEOPLASTIC LESIONS 484 Mediastinal Cysts and Inflammatory Lesions Ming Guo, MD and Savitri Krishnamurthy, MD NEOPLASMS 486 Thymoma Ming Guo, MD and Savitri Krishnamurthy, MD 488 Thymic Carcinoma Ming Guo, MD and Savitri Krishnamurthy, MD 490 Germ Cell Tumors Ming Guo, MD and Savitri Krishnamurthy, MD 492 Neurogenic Tumors Ming Guo, MD and Savitri Krishnamurthy, MD 494 Metastatic Tumors of Mediastinum Ming Guo, MD and Savitri Krishnamurthy, MD

OVERVIEW 498 Cytology of Normal Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD 500 Inflammatory and Infectious Conditions of Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD BENIGN HEPATIC NEOPLASMS 502 Hepatocellular Adenoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD

504 Focal Nodular Hyperplasia Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD 506 Hemangioma, Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD MALIGNANT NEOPLASMS 508 Hepatocellular Carcinoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD 510 Hepatoblastoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD 512 Liver Metastasis Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD

OVERVIEW 516 Cytology of Normal Kidney Yimin Ge, MD BENIGN LESIONS AND NEOPLASMS 518 Renal Cysts Yimin Ge, MD 520 Angiomyolipoma Yimin Ge, MD 522 Oncocytoma, Kidney Yimin Ge, MD 524 Metanephric Adenoma Yimin Ge, MD and Jun Zhang, MD, MS 526 Metanephric Stromal Tumor Yimin Ge, MD and Norma Quintanilla, MD 527 Xanthogranulomatous Pyelonephritis/Malakoplakia Yimin Ge, MD MALIGNANT NEOPLASMS 528 Clear Cell Renal Cell Carcinoma Yimin Ge, MD 532 Papillary Renal Cell Carcinoma Yimin Ge, MD 534 Clear Cell Papillary Renal Cell Carcinoma Michael J. Thrall, MD 536 Chromophobe Renal Cell Carcinoma Yimin Ge, MD 538 TFE3- andTFEB-Rearranged Renal Cell Carcinomas Michael J. Thrall, MD 540 Collecting Duct Carcinoma Yimin Ge, MD and Jun Zhang, MD, MS 541 Renal Medullary Carcinoma Yimin Ge, MD 542 Mucinous Tubular and Spindle Cell Carcinoma of Kidney Yimin Ge, MD 543 Carcinoid Tumor Yimin Ge, MD 544 Primary Renal Sarcomas in Adults Yimin Ge, MD and Jun Zhang, MD, MS 545 Renal Lymphomas Yimin Ge, MD and Jun Zhang, MD, MS 546 Nephroblastoma (Wilms Tumor) Yimin Ge, MD, Jun Zhang, MD, MS, and Norma Quintanilla, MD 548 Clear Cell Sarcoma of Kidney Yimin Ge, MD and Norma Quintanilla, MD 550 Congenital Mesoblastic Nephroma Yimin Ge, MD and Norma Quintanilla, MD 552 Rhabdoid Tumor of Kidney Yimin Ge, MD and Norma Quintanilla, MD 553 Metastatic Tumors to Kidney Yimin Ge, MD TUMORS OF RENAL PELVIS 554 Urothelial Carcinoma Yimin Ge, MD

OVERVIEW 558 Cytology of Normal Adrenal Gland Yimin Ge, MD ADRENAL CORTICAL LESIONS 560 Adrenal Cortical Adenoma Yimin Ge, MD 562 Adrenal Cortical Carcinoma Yimin Ge, MD 564 Metastatic Tumors to Adrenal Gland Yimin Ge, MD ADRENAL MEDULLARY LESIONS 566 Pheochromocytoma Yimin Ge, MD

OVERVIEW 570 Cytology of Normal Pancreas Uma Kundu, MD and Dina R. Mody, MD 572 Pancreaticobiliary Cytology Reporting Terminology, Cyst Evaluation Dina R. Mody, MD and Mary R. Schwartz, MD NONNEOPLASTIC LESIONS 574 Pancreatitis Uma Kundu, MD and Dina R. Mody, MD 576 Lymphoepithelial Cyst of Pancreas Dina R. Mody, MD 577 Intra- and Peripancreatic Splenules Dina R. Mody, MD 578 Serous Microcystic Adenoma Uma Kundu, MD and Savitri Krishnamurthy, MD

Mucinous Cystic Neoplasm Uma Kundu, MD and Savitri Krishnamurthy, MD 582 Intraductal Papillary Mucinous Neoplasm Uma Kundu, MD and Savitri Krishnamurthy, MD 584 Solid Pseudopapillary Neoplasm Gene Landon, MD and Savitri Krishnamurthy, MD 586 Pancreatic Neuroendocrine Tumor Gene Landon, MD and Savitri Krishnamurthy, MD 588 Pancreatic Ductal Adenocarcinoma Gene Landon, MD and Savitri Krishnamurthy, MD Unusual Variants of Ductal Carcinoma Savitri Krishnamurthy, MD 594 Acinar Cell Carcinoma Savitri Krishnamurthy, MD 596 Lymphoma and Secondary Tumors of Pancreas Savitri Krishnamurthy, MD

OVERVIEW Approach to Cytologic/Small Biopsy Diagnosis of Primary Bone Tumors Dina R. Mody, MD NEOPLASMS 602 Chondromas of Bone and Soft Tissue Mukul K. Divatia, MD and Dina R. Mody, MD 604 Chondroblastoma Dina R. Mody, MD 606 Giant Cell Tumor Dina R. Mody, MD 608 Osteoblastoma Dina R. Mody, MD Adamantinoma Dina R. Mody, MD 612 Langerhans Cell Histiocytosis Dina R. Mody, MD 614 Chordoma Dina R. Mody, MD 616 Osteosarcoma Savitri Krishnamurthy, MD Chondrosarcoma Savitri Krishnamurthy, MD 624 Ewing Sarcoma Savitri Krishnamurthy, MD 628 Bone Lymphoma Dina R. Mody, MD Metastatic Tumors of Bone Dina R. Mody, MD

OVERVIEW 634 Approach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue Lesions Dina R. Mody, MD ADIPOCYTIC TUMORS 636 Benign Adipose Tissue Tumors Uma Kundu, MD and Savitri Krishnamurthy, MD 638 Liposarcoma Uma Kundu, MD and Savitri Krishnamurthy, MD FIBROBLASTIC/MYOFIBROBLASTIC LESIONS 642 Fibrosarcoma Uma Kundu, MD and Savitri Krishnamurthy, MD 644 Myofibroblastoma Savitri Krishnamurthy, MD 646 Low-Grade Myofibroblastic Sarcoma Uma Kundu, MD and Savitri Krishnamurthy, MD FIBROHISTIOCYTIC TUMORS 648 Giant Cell Tumor of Tendon Sheath Uma Kundu, MD and Savitri Krishnamurthy, MD 650 Undifferentiated Pleomorphic Sarcoma Uma Kundu, MD and Savitri Krishnamurthy, MD TUMORS OF MUSCLE ORIGIN 652 Smooth Muscle Tumors Gene Landon, MD and Savitri Krishnamurthy, MD 654 Skeletal Muscle Tumors Gene Landon, MD and Savitri Krishnamurthy, MD VASCULAR TUMORS 658 Hemangioma, Soft Tissue Gene Landon, MD and Michael J. Thrall, MD 660 Epithelioid Hemangioendothelioma Gene Landon, MD and Michael J. Thrall, MD 662 Angiosarcoma Gene Landon, MD and Savitri Krishnamurthy, MD OTHER TUMORS 664 Other Reactive and Neoplastic Soft Tissue Entities Dina R. Mody, MD 666 Mesenchymal Chondrosarcoma Dina R. Mody, MD 667 Solitary Fibrous Tumor Dina R. Mody, MD 668 Intramuscular Myxoma Gene Landon, MD and Savitri Krishnamurthy, MD 670 Synovial Sarcoma Gene Landon, MD and Savitri Krishnamurthy, MD 672 Epithelioid Sarcoma Gene Landon, MD and Savitri Krishnamurthy, MD 674 Alveolar Soft Part Sarcoma Uma Kundu, MD and Savitri Krishnamurthy, MD 676 Clear Cell Sarcoma of Soft Tissue Uma Kundu, MD and Savitri Krishnamurthy, MD 678 Desmoplastic Small Round Cell Tumor Uma Kundu, MD and Savitri Krishnamurthy, MD

682 Approach to Ophthalmic Cytology Patricia Chévez-Barrios, MD 686 Ophthalmic Cytopathology, Infectious Patricia Chévez-Barrios, MD 690 Ophthalmic Cytopathology, Neoplastic Patricia Chévez-Barrios, MD 696 Neuropathology Squash Preparations, Infectious Andreana L. Rivera, MD, Suzanne Z. Powell, MD, and Hidehiro Takei, MD 700 Neuropathology Squash Preparations, Glial Neoplasms Suzanne Z. Powell, MD, Andreana L. Rivera, MD, and Hidehiro Takei, MD 704 Neuropathology Squash Preparations, Nonglial Neoplasms Andreana L. Rivera, MD, Suzanne Z. Powell, MD, and Hidehiro Takei, MD

Part V: Management and Ancillary Testing

710 Cytopreparatory Techniques and Instrumentation in Nongynecologic Cytology Debora A. Smith, CT(ASCP) and Dina R. Mody, MD 716 Quality Improvement and Laboratory Management for Cytopathology Debora A. Smith, CT(ASCP) and Dina R. Mody, MD

Savitri Krishnamurthy, MD