Diagnostic Pathology: Spleen

SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN

NORMAL HISTOLOGY

4 Introduction to Spleen

Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD

12 Imaging of Splenic Disorders

Mohammad A. Vasef, MD

18 Handling, Processing, and Gross Pathology of Spleen

Mohammad A. Vasef, MD

26 Fine-Needle Aspiration and Core Biopsy of Spleen

Mohammad A. Vasef, MD

32 Immunohistochemistry of Spleen

Aaron Auerbach, MD, MPH

40 Flow Cytometry

Nadine Aguilera, MD

46 Molecular Techniques

Nadine Aguilera, MD

SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS

LYMPHOID HYPERPLASIA

54 Florid Follicular Hyperplasia

Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

56 Autoimmune Disease

Nadine Aguilera, MD

62 HIV in Spleen

Nadine Aguilera, MD

68 Castleman Disease

Nadine Aguilera, MD

70 Marginal Zone Hyperplasia

Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

GRANULOMATOUS LESIONS/DISORDERS

72 Lipogranulomas

Jeffrey Vos, MD

78 Sarcoidosis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

82 Chronic Granulomatous Disease

Aaron Auerbach, MD, MPH

INFECTIONS

86 Mycobacteriosis

Nadine Aguilera, MD

90 Selected Bacterial Infections

Aaron Auerbach, MD, MPH

94 Candidiasis

Aaron Auerbach, MD, MPH

96 Histoplasmosis

Nadine Aguilera, MD

98 Cryptococcosis

Nadine Aguilera, MD

100 Coccidioidomycosis

Aaron Auerbach, MD, MPH

104 Pneumocystosis

Aaron Auerbach, MD, MPH

108 Infectious Mononucleosis

Nadine Aguilera, MD

112 Cytomegalovirus Infection

Nadine Aguilera, MD

114 Herpes Simplex Virus Infection

Aaron Auerbach, MD, MPH and Nadine Aguilera, MD

116 Echinococcosis

Aaron Auerbach, MD, MPH

120 Malaria

Nadine Aguilera, MD

NONINFECTIOUS CYSTS

122 Epithelial Cyst

Ellina Hall, DO and Aaron Auerbach, MD, MPH

124 False Cyst

Ellina Hall, DO and Aaron Auerbach, MD, MPH

NONNEOPLASTIC VASCULAR PROCESSES

126 Chronic Passive Congestion

Ellina Hall, DO and Aaron Auerbach, MD, MPH

128 Infarct

Jeffrey Vos, MD

136 Peliosis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

RED CELL DISORDERS

144 Sickle Cell Disease

Aaron Auerbach, MD, MPH and Ellina Hall, DO

146 Thalassemia

Nadine Aguilera, MD and Aaron Auerbach, MD, MPH

150 Hereditary Spherocytosis

Nadine Aguilera, MD

152 Thrombotic Thrombocytopenic Purpura

Aaron Auerbach, MD, MPH

MISCELLANEOUS LESIONS/DISORDERS

158 Heterotaxy Syndromes

Aaron Auerbach, MD, MPH

160 Congenital Splenic Abnormalities

Nadine Aguilera, MD

164 Extramedullary Hematopoiesis

Ellina Hall, DO and Aaron Auerbach, MD, MPH

166 Gamna-Gandy Bodies

Nadine Aguilera, MD

168 Hemophagocytic Lymphohistiocytosis

Nadine Aguilera, MD

174 Immune Thrombocytopenic Purpura

Ellina Hall, DO and Aaron Auerbach, MD, MPH

178 Niemann-Pick Disease

Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD

184 Gaucher Disease

Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD

188 Sea-Blue (Ceroid) Histiocytosis

Mohammad A. Vasef, MD

192 Gangliosidosis Lysosomal Disorder

Mohammad A. Vasef, MD

194 Therapy Effect on Spleen

Aaron Auerbach, MD, MPH

202 Traumatic and Nontraumatic Splenic Injuries

Mohammad A. Vasef, MD

SECTION 3: NEOPLASTIC SPLENIC DISORDERS

BENIGN MESENCHYMAL LESIONS

208 Introduction to Vascular Lesions

Nadine Aguilera, MD

210 Hemangioma

Nadine Aguilera, MD

218 Lymphangioma

Nadine Aguilera, MD

222 Littoral Cell Angioma

Nadine Aguilera, MD

228 Inflammatory Pseudotumor

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

242 Splenic Hamartoma

Nadine Aguilera, MD

246 Myelolipoma

Aaron Auerbach, MD, MPH

MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS

248 Angiosarcoma

Nadine Aguilera, MD

256 Hemangioendothelioma

Nadine Aguilera, MD

258 Kaposi Sarcoma

Nadine Aguilera, MD

260 Leiomyosarcoma

Aaron Auerbach, MD, MPH

266 Gastrointestinal Stromal Tumor

Aaron Auerbach, MD, MPH

272 Follicular Dendritic Cell Sarcoma

Aaron Auerbach, MD, MPH

280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

286 Langerhans Cell Histiocytosis

Guanghua Wang, MD

292 Histiocytic Sarcoma

Nadine Aguilera, MD

LYMPHOMA

300 Introduction to Lymphoma

Mohammad A. Vasef, MD

310 Splenic Marginal Zone Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

318 Hairy Cell Leukemia

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

326 Hairy Cell Leukemia Variant

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

334 Lymphoplasmacytic Lymphoma

Aaron Auerbach, MD, MPH

342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

350 Follicular Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

358 Mantle Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

366 Leukemic Nonnodal Mantle Cell Lymphoma

Mohammad A. Vasef, MD

370 Splenic Diffuse Red Pulp B-Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

376 B-Cell Prolymphocytic Leukemia

Aaron Auerbach, MD, MPH and Nadine Aguilera, MD

378 Diffuse Large B-Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst

Mohammad A. Vasef, MD

390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Jeffrey Vos, MD

398 Burkitt Lymphoma

Aaron Auerbach, MD, MPH

406 Classic Hodgkin Lymphoma

Jeffrey Vos, MD

416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Aaron Auerbach, MD, MPH

426 Peripheral T-Cell Lymphoma, Unspecified

Mohammad A. Vasef, MD

432 Hepatosplenic T-Cell Lymphoma

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

440 T-Cell Prolymphocytic Leukemia

Mohammad A. Vasef, MD

448 T-Cell Large Granular Lymphocytic Leukemia

Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD

456 Aggressive NK-Cell Leukemia

Aaron Auerbach, MD, MPH

462 Transformation of Splenic Disorders

Nadine Aguilera, MD

LEUKEMIA

466 Acute Myeloid Leukemia

Nadine Aguilera, MD

474 Lymphoblastic Leukemia/Lymphoma

Nadine Aguilera, MD

CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES

480 Myeloproliferative Neoplasm Overview

Nadine Aguilera, MD

482 Chronic Myeloid Leukemia, BCR::ABL1 Positive

Nadine Aguilera, MD

488 Essential Thrombocythemia

Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH

492 Polycythemia Vera

Guanghua Wang, MD

496 Primary Myelofibrosis

Jeffrey Vos, MD

506 Mastocytosis

Mohammad A. Vasef, MD

514 Chronic Myelomonocytic Leukemia

Mohammad A. Vasef, MD

PLASMA CELL-ASSOCIATED DISORDERS

520 Amyloidosis

Nadine Aguilera, MD

526 Heavy Chain Disease

Aaron Auerbach, MD, MPH

530 Plasma Cell Myeloma/Plasmacytoma

Nadine Aguilera, MD and Aaron Auerbach, MD, MPH

METASTASIS

534 Metastatic Tumors

Ellina Hall, DO and Aaron Auerbach, MD, MPH