This issue of Surgical Pathology Clinics, guest edited by Dr. Jessica Davis, is devoted to Challenges & Updates in Pediatric Pathology. Articles in this issue include:: Advances and Pitfalls in the Diagnosis of Hirschsprungs Disease, Updates in Pediatric Enteropathies:: Differential Diagnosis, Testing, and Genetics, Pediatric Liver Tumors:: Updates in Classification, New Prognostic Indicators in Pediatric Adrenal Tumors:: Neuroblastoma & Adrenal Cortical Tumors, Pediatric Cystic Lung Lesions, Strategies for the Neonatal Lung Biopsy:: Histology to Genetics, Wilms Tumor:: Challenges and Newcomers in Prognosis, Pediatric Renal Tumors:: Updates in the Molecular Era, Newcomers in Vascular Anomalies, Spindle Cell Rhabdomyosarcoma:: Further Subcategorization, Pediatric & Infantile Fibroblastic/myofibroblastic Tumors in the Molecular Era, Round Cell Sarcomas:: Newcomers and Diagnostic Approaches, CNS Embryonal Tumors:: Testing Strategies for Integrated Diagnosis, Updates in Pediatric Gliomas, and more.