This issue of Nursing Clinics, Guest Edited by Mimi Mahon, features subject topics such as:: Understanding Childrens Involvment in Medical Decision Making; Symptom Management at End of Life; Assessing respiratory distress when the patient cant self-report; Barriers to Palliative Care, Legislative Issues; End Stage Liver Disease:: Symptoms & Practice Implications; Dying children:: Creating opportunities out of a Last Chance”; Decision making in palliative care; Discussing a family members serious illness:: childrens and families perspectives; Living with cognitive impairments in Long Term Care:: Palliative Care & End of Life implications; Withdrawal of Life-Sustaining Therapy; The patient and family perspectives:: Living with cancer; Palliative care concepts in the sickle cell population.