In this issue of Hematology/Oncology Clinics, guest editor Dr. Thomas E. Clancy brings his considerable expertise to the topic of Liver and Biliary Tract Cancers. From improved systemic therapies including targeted therapies and immunotherapy, to improved local therapy including ablative technology and minimally invasive surgery, treatment options for liver and biliary tract cancers continue to evolve. This issue provides a comprehensive review of liver and biliary malignancies, including diagnosis and pathologic characterization, systemic and local therapies, and palliative treatment.