A role for triterpenes in the cancer setting is gradually emerging. Bringing together the efforts of both academy and industry, this book highlights the most significant research results achieved with pentacyclic triterpenic compounds, providing clues for lead compound selection and targets to be exploited. It will work as an extension of the continuous discussion concerning the introduction of these agents into the clinical setting for chemotherapy and chemoprevention purposes.
Preface; The Pentacyclic Triterpenes; Enzymatic Synthesis of Cyclic Triterpenes; Cytotoxic Action of Natural Pentacyclic Triterpenes on Cancer Cells:: Lupane-type Compounds; Oleanane-, Ursane-, Lupane-, & Taraxasterane-type Pentacyclic Triterpenes Isolated from the Medicinal Plants Nerium oleander, Ixeris chinensis, Sonchus oleraceus & Phytolacca americana. Cytotoxicity Studies on Human Cancer Cell Lines, & MDR Cancer Reversal & Anti-Inflammatory Activities; Cancer Chemo-preventive Agents:: Natural Pentacyclic Triterpenoids; Semisynthetic Lupane Triterpenes with Cytotoxic Activity; Semisynthetic Pentacyclic Triterpenoids in the Cancer setting:: Oleanolic Acid & its Derivatives; Semisynthetic Pentacyclic Triterpenoids in the Cancer Setting:: Ursolic Acid & its Derivatives; Highlights of Pentacyclic Triterpenes in the Cancer Setting; Index.
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