The majority of this issue is devoted to Head and Neck Squamous Cell Carinoma (HNSCC), but a few articles are devoted to nasopharyngeal cancer and malignancies of the salivary and thyroid glands. Dr. Siu has gathered her esteemed colleagues to give a thorough overview on the most up-to-date clinical information devoted to HNSCC. Articles address molecular targeting of HNSCC, induction chemotherapy, functional imaging, surgical innovation, and intensity-modulated radiotherapy and image-guided radiotherapy.