Welcome to the state-of -the-art 2nd edition of Molecular Basis of Cancer! This acclaimed reference incorporates the latest advances and newest research, to give you thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for cancer therapy.
Youll find a broad update on new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Each chapter discusses the clinical implications for treatment while numerous examples of the latest clinical interventions help you understand and assess the products of the biotechnology revolution!
Section I: Malignant Transformation 1. Cancer: A Genetic Disorder 2. Regulation of the Cell Cycle 3. Programmed Cell Death and Senescence 4. Progressive Genetic Abnormalities in Human Neoplasia 5. Viral Carcinogenesis 6. Tumor Suppressor Genes 7. Oncogenes and Signal Transduction
Section II: Growth and Spread of Cancer 8. Growth Factors and Their Receptors in Epithelial Malignancies Metastasis and Angiogenesis: Molecular Dissection and Novel Applications 9. Adhesions and Mechanisms 10. Tumor Angiogenesis and Antiangiogenesis
Section III: Molecular Pathogenesis of Specific Malignancies 11. Molecular Biology of Non-Hodgkins Lymphoma and Multiple Myeloma 12. Molecular Genetics of Acute Lymphoblastic Leukemia 13. Molecular Biology of Childhood Neoplasms 14. Molecular Biology of Lung Cancer 15. Molecular Abnormalities in Colon and Rectal Cancer 16. Molecular Basis of Breast Cancer 17. Prostate Cancer 18. Molecular Pathogenesis of Ovarian Cancer 19. Molecular Biology of Melanoma
Section IV: Molecular Basis of Cancer Therapy 20. Natural and Acquired Resistance to Chemotherapeutic Agents 21. Radiation Therapy 22. Monoclonal Antibodies 23. Interferons and Hematopoietic Cytokines 24. Cellular Immunity and Cytokines 25. Cancer-Specific Vaccines 26. Molecular Basis of Cancer Therapy 27. Molecular Markers in Cancer Therapy: Evolution of a Concept 28. Molecular Mechanisms of Chemoprevention and Differentiation Therapy 29. Counseling for Hereditary Cancer Risk
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