In this issue of Nursing Clinics of North America, guest editors Linda M. Wesp and Tonia Poteat bring their considerable expertise to the topic of Caring for Transgender and Gender-Diverse People. Top experts review best practices in gender-affirming nursing care across the lifespan, including specifics about evidence-based perioperative care, primary care and prevention, chronic disease and stress, mental health, sexual health, and reproductive health. This issue also provides an overview of the political-legal landscape around gender-affirming care, as well as best practices in nursing education for preparing pre-licensure and advance practice nurses to care for transgender and gender-diverse populations.