In this issue of Critical Care Nursing Clinics, guest editors Elizabeth Scruth and Vanessa A. Martinez bring their considerable expertise to the topic of Innovations in Critical Care Nursing. Innovations in critical care nursing-in areas such as care delivery models, nurse-led initiatives, and virtual nursing-are pivotal in enhancing both patient and nurse satisfaction, reducing practice pain points, and improving patient outcomes. This issue highlights these areas and provides the information critical care nurses need to drive meaningful improvements in patient outcomes and overall healthcare quality.