In this issue of Critical Care Nursing Clinics, guest editors Heather Przybyl and Dana Lauer bring their considerable expertise to the topic of Management of Critical Care Patients with Respiratory Alterations. Respiratory alterations are common indications for admission to the intensive care unit, and implementing evidence-based guidelines for treating these patients is imperative for improving outcomes and reducing mortality. In this issue, top experts discuss alterations in pulmonary function, care management of these alterations, adjunctive therapies, ventilator management guidelines, and more.