Non-motor Parkinsons Disease is a burgeoning area of the movement disorders field, as patients increasingly live longer and encounter more late-stage symptoms. The spectrum of non-motor manifestations spans much of the body, with non-motor features occurring in all stages of the disease. Identification of symptoms is key for preserving quality of life and successful treatment. This is a practical manual on all aspects of pre-motor and non-motor manifestations of Parkinsons. The genetic causes of non-motor symptoms are detailed and methods of patient evaluation summarized. Topics such as autonomic and sexual dysfunction, mood disorders, and drug-induced symptoms of non-motor Parkinsons are covered in depth. This is an essential resource for movement disorder specialists, neurologists and other clinicians involved in caring for those with Parkinsons disease.
Introduction; 1. Parkinsons disease: an overview of non-motor symptomatology Valentina Leta, Daniel van Wamelen and Ray Chaudhuri; 2. Evaluation of the patient with Parkinsons disease in the early stages: non-motor phase Anna Sauerbier, Daniele Urso, Chloe Farrell, K. Ray Chaudhuri and Carmen Rodriguez-Blazquez; 3. Non-motor symptoms in late-stage Parkinsons disease Umar Shuaib, Adam Margolius and Hubert Fernandez; 4. Neuropathology of non-motor Parkinsons disease symptoms Lea Grinberg and Helmut Heinsen; 5. Neuroimaging studies in non-motor Parkinsons disease symptoms David Brooks; 6. Mild cognitive impairment Amos D. Korczyn; 7. Cognitive dysfunction in Parkinsons disease Damon Salzman and Shakeel Tabish; 8. Neuropsychiatric (behavioral) symptoms in Parkinsons disease Kasia Rothenberg; 9. Mood disorders in patients with Parkinsons disease Po-Heng Tsai and Ganesh Gopalakrishna; 10. Olfactory dysfunction in Parkinsons disease and related disorders Richard Doty and Christopher Hawkes; 11. Oculomotor and visual-vestibular disturbances in Parkinsons disease Adolfo Bronstein, Aasef Shaikh, Tim Anderson, Michael MacAskill and Diego Kaski; 12. Autonomic dysfunction and failure in Parkinsons disease Thomas Foki, Birgit Riemer, Bianca Brim and Walter Struhal; 13. Gastrointestinal disturbances in Parkinsons disease, including the management of Sialorrhea Wolfgang H. Jost and Lisa Klingelhoefer; 14. Sexual dysfunction in Parkinsons disease Gila Bronner and Tanya Gurevich; 15. Sleep disturbances in Parkinsons disease, including rapid eye movement behavior disorders Cristian Falup-Pecurariu, ?tefania Diaconu and Maria-Lucia Muntean; 16. Musculoskeletal disorders and pain in Parkinsons disease Ovidiu Bajenaru; 17. Cutaneous manifestations of Parkinsons disease Rivka Inzelberg and Esther Azizi; 18. Genetics of non-motor symptoms of Parkinsons disease Ziv Gan-Or, Konstantin Senkevich and Roy Alcalay; 19. Drug-induced non-motor symptoms of Parkinsons disease Camila Aquino; 20. Impulse control disorders and the dopamine dysregulation syndrome Atbin Djamshidian, Guillaume Pagnier, Michael J Frank and Joseph H. Friedman; 21. Serotonin syndrome and drug interactions, hypertensive complications, and adverse effects of Monoamine oxidase inhibitors in patients with Parkinsons disease Kailash Bhatia and Eoin Mulroy; 22. Parkinsons disease and pregnancy Shira McMahan, Ramon Lugo-Sanchez and Nestor Galvez-Jimenez.
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